Corić V, Culig J, Zoricić I, Sallmani A, Mikulandra S, Bogdan S, Simicević V, Bulić K, Kolega M, Derniković K
Center for Digestive Diseases, Medical and Veterinary Faculty, University of Zagreb, Croatia.
J Physiol Paris. 1993;87(5):335-7. doi: 10.1016/0928-4257(93)90040-z.
The main purpose of this study was to further investigate the effects of vagotomy on gastric lesion development. In contrast to the usual subdiaphragmal vagotomy, a different vagotomy at the level of the trigonum caroticum was used both alone and in combination with pylorus ligation (done immediately after vagal transection). The animals were killed 15 min, 30 min, 1 h and 6 h following vagotomy. No damaging effects of sham-vagotomy, or obvious negative effects of cervical vagotomy were noted. Prominent lesions appeared after 1 h in rats subjected to cervical vagotomy and significantly increased lesions in the early period of pylorus ligation were noted. No further aggravation in pylorus ligated rats (even an apparent amelioration at 1-h interval) and no lesions in rats with cervical vagotomy in the latter period could be explained in terms of a lack of reactivity due to exhaustion preceding fatal outcome. Consistent with this, the rats subjected to cervical vagotomy died shortly after the 6-h period.
本研究的主要目的是进一步探究迷走神经切断术对胃损伤发展的影响。与通常的膈下迷走神经切断术不同，本研究采用了在颈动脉三角水平进行的不同迷走神经切断术，该手术单独使用或与幽门结扎术联合使用（在迷走神经横断后立即进行幽门结扎）。在迷走神经切断术后15分钟、30分钟、1小时和6小时处死动物。未观察到假迷走神经切断术的损伤作用，也未发现颈迷走神经切断术有明显的负面影响。接受颈迷走神经切断术的大鼠在1小时后出现明显损伤，且在幽门结扎早期发现损伤显著增加。幽门结扎大鼠未出现进一步加重的情况（甚至在1小时间隔时明显改善），颈迷走神经切断术大鼠在后期未出现损伤，这不能用致命结局前因耗竭导致的反应性缺乏来解释。与此一致的是，接受颈迷走神经切断术的大鼠在6小时后不久死亡。
