Ganguly A K, Gopinath P
Q J Exp Physiol Cogn Med Sci. 1979 Jan;64(1):1-6. doi: 10.1113/expphysiol.1979.sp002453.
Gastric tissue histamine concentration was determined, 6 and 16 hours after pylorus ligation in vagus intact and vagotomized albino rats and the results were compared with those of respective control animals, sacrificed, 6 and 16 hours after ether anaesthesia alone. The gastric tissue histamine concentration of rats subjected to none of the experimental situations was also determined and taken into comparison. The results show that the stress of pylorus ligation reduced the gastric tissue histamine concentration, the reduction being more with increased duration of stress. On the other hand, subdiaphragmatic vagtomy preserved the histamine concentration of gastric tissue irrespective of the duration to which the animals were exposed following pylorus ligation. It appears that increase in vagal discharges during stress leads to increased liberation of histamine from the gastric wall, thereby, reducing the gastric tissue histamine concentration; the reduction being proportional to the duration of stress and increase in vagal discharges, whereas, in the absence of vagal impulses following subdiaphragmatic vagotomy, the gastric tissue histamine concentration is preserved in spite of the stress to which the animals were exposed.
在迷走神经完整和切断迷走神经的白化大鼠幽门结扎术后6小时和16小时，测定胃组织组胺浓度，并将结果与仅在乙醚麻醉后6小时和16小时处死的相应对照动物的结果进行比较。还测定了未经历任何实验情况的大鼠的胃组织组胺浓度并进行比较。结果表明，幽门结扎应激降低了胃组织组胺浓度，应激持续时间越长，降低越明显。另一方面，膈下迷走神经切断术可保持胃组织组胺浓度，而与幽门结扎后动物暴露的持续时间无关。似乎应激期间迷走神经放电增加会导致组胺从胃壁释放增加，从而降低胃组织组胺浓度；降低程度与应激持续时间和迷走神经放电增加成正比，而在膈下迷走神经切断术后没有迷走神经冲动的情况下，尽管动物受到应激，但胃组织组胺浓度仍得以保持。
