使用催化串联氨基钯化反应的子午线素和梅罗林的简明合成。
Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction.
机构信息
School of Chemistry and Physics, University of Adelaide , Adelaide, SA, Australia.
出版信息
Org Lett. 2014 Feb 7;16(3):708-11. doi: 10.1021/ol403390m. Epub 2014 Jan 17.
PMID:24437527
Abstract
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory natural products has been developed. The sequence utilizes a variation of the Cacchi palladium-catalyzed domino reaction to efficiently construct the heterocyclic framework of the meridianins and meriolins from monocyclic precursors.
摘要
已经开发出了一种将天然和合成的 meridianin 家族激酶抑制天然产物成员进行综合的方法。该序列利用了 Cacchi 钯催化的多米诺反应的变体，从单环前体高效构建了 meridianin 和 meriolin 的杂环骨架。
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