通过一锅法 Masuda 硼化-Suzuki 偶联序列简洁合成海洋（双）吲哚生物碱 Meridianin C、D、F 和 G 以及 Scalaridine A。
Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence.
机构信息
Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
出版信息
Molecules. 2022 Mar 30;27(7):2233. doi: 10.3390/molecules27072233.
Abstract
-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation-Suzuki coupling (MBSC) sequence. This methodology was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield.
摘要
受保护的 3-碘吲哚与（二）嗪卤化物在顺序 Pd 催化一锅法中反应，即通过 Masuda 硼酸化-Suzuki 偶联（MBSC）序列。该方法成功应用于海洋吲哚生物碱子午线素 C、D、F 和 G 的简洁合成，以及双吲哚生物碱 scalaridine A 的合成，产率中等至优秀。
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