自体纤维蛋白组织粘合剂的生物降解及全身效应。

Autologous fibrin tissue adhesive biodegration and systemic effects.

作者信息

Harris D M, Siedentop K H, Ham K R, Sanchez B

机构信息

Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine at Chicago.

出版信息

Laryngoscope. 1987 Oct;97(10):1141-4. doi: 10.1288/00005537-198710000-00003.

DOI:10.1288/00005537-198710000-00003

PMID:2443780

Abstract

A series of experiments was conducted to investigate the rate of Autologous Fibrin Tissue Adhesive (AFTA) degradation by the fibrinolysis inhibitor, epsilon amino caproic acid (EACA). The duration of AFTA clots in vitro, subcutaneous, and in the middle ear was prolonged for a time interval that was proportional to the concentration of EACA in Component II of the adhesive. No toxic reactions were observed in the middle or inner ear. Systemic pathology (thrombosis or emboli) could not be related to the presence of EACA applied in the middle ear or directly into the blood stream at concentrations (mg/kg body weight) up to 1,500 times that expected to occur during surgery on humans.

摘要

进行了一系列实验，以研究纤维蛋白溶解抑制剂ε-氨基己酸（EACA）对自体纤维蛋白组织粘合剂（AFTA）的降解速率。AFTA凝块在体外、皮下和中耳中的持续时间延长，延长的时间间隔与粘合剂II组分中EACA的浓度成正比。在中耳或内耳未观察到毒性反应。全身病理学（血栓形成或栓子）与在中耳应用EACA或直接以高达人类手术预期浓度（毫克/千克体重）的1500倍的浓度注入血流无关。