Infectious Diseases Unit, University of Caen, Caen, France.
Clin Microbiol Infect. 2014 Sep;20(9):908-11. doi: 10.1111/1469-0691.12545. Epub 2014 Feb 20.
Campylobacter has been associated with immunoproliferative small intestinal disease (IPSID), on the basis of 16S rDNA sequencing, in situ hybridization, and immunohistochemistry. Here, for the first time, we have cultured Campylobacter from the stools of a patient with IPSID. Phenotypic analysis and whole genome sequencing identified Campylobacter coli. PCR on a IPSID tissue biopsy sample was positive for Campylobacter coli and negative for Campylobacter jejuni. These findings further support a causative role for Campylobacter in the development of IPSID.
基于 16S rDNA 测序、原位杂交和免疫组织化学，弯曲杆菌与免疫增生性小肠疾病（IPSID）相关。在这里，我们首次从 IPSID 患者的粪便中培养出弯曲杆菌。表型分析和全基因组测序鉴定出大肠弯曲杆菌。IPSID 组织活检样本的 PCR 检测结果为大肠弯曲杆菌阳性，空肠弯曲杆菌阴性。这些发现进一步支持弯曲杆菌在 IPSID 发展中的致病作用。
