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GPR109a：微生物组与健康之间缺失的一环？

GPR109a: the missing link between microbiome and good health?

机构信息

Department of Medicine, Department of Infectious Diseases & Pathology, University of Florida, Gainesville, FL 32611, USA.

出版信息

Immunity. 2014 Jan 16;40(1):8-10. doi: 10.1016/j.immuni.2013.12.009.

DOI:10.1016/j.immuni.2013.12.009
PMID:24439263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4337780/
Abstract

A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, Singh et al. (2014) demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.

摘要

宿主与庞大的肠道微生物生态系统之间存在着复杂的相互关系，为众多生物学活动提供服务，包括营养、免疫和屏障功能。在本期《免疫》杂志中，Singh 等人（2014）证明了微生物衍生的丁酸盐通过 GPR109a 信号传导发挥其抗炎和结直肠癌保护作用。

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本文引用的文献

1
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.Gpr109a 的激活，作为烟酸和共生代谢物丁酸盐的受体，可抑制结肠炎症和癌变。
Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.
2
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.共生菌产生的代谢物可促进外周调节性 T 细胞的生成。
Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.
3
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.共生微生物衍生的丁酸盐诱导结肠调节性 T 细胞的分化。
Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4
The microbiome and cancer.微生物组与癌症。
Nat Rev Cancer. 2013 Nov;13(11):800-12. doi: 10.1038/nrc3610. Epub 2013 Oct 17.
5
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.微生物代谢产物，短链脂肪酸，调节结肠 Treg 细胞稳态。
Science. 2013 Aug 2;341(6145):569-73. doi: 10.1126/science.1241165. Epub 2013 Jul 4.
6
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.短链脂肪酸激活肠道上皮细胞上的 GPR41 和 GPR43，促进小鼠的炎症反应。
Gastroenterology. 2013 Aug;145(2):396-406.e1-10. doi: 10.1053/j.gastro.2013.04.056. Epub 2013 May 7.
7
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Host-gut microbiota metabolic interactions.宿主-肠道微生物群代谢相互作用。
Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.
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