GPR109a：微生物组与健康之间缺失的一环？
GPR109a: the missing link between microbiome and good health?
机构信息
Department of Medicine, Department of Infectious Diseases & Pathology, University of Florida, Gainesville, FL 32611, USA.
出版信息
Immunity. 2014 Jan 16;40(1):8-10. doi: 10.1016/j.immuni.2013.12.009.
Abstract
A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, Singh et al. (2014) demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.
摘要
宿主与庞大的肠道微生物生态系统之间存在着复杂的相互关系，为众多生物学活动提供服务，包括营养、免疫和屏障功能。在本期《免疫》杂志中，Singh 等人（2014）证明了微生物衍生的丁酸盐通过 GPR109a 信号传导发挥其抗炎和结直肠癌保护作用。
相似文献
1
GPR109a: the missing link between microbiome and good health?GPR109a：微生物组与健康之间缺失的一环？
Immunity. 2014 Jan 16;40(1):8-10. doi: 10.1016/j.immuni.2013.12.009.
2
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.Gpr109a 的激活，作为烟酸和共生代谢物丁酸盐的受体，可抑制结肠炎症和癌变。
Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.
3
Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis.异常进食模式导致昼夜节律紊乱，并促进酒精相关性结直肠癌发生。
Cell Mol Gastroenterol Hepatol. 2020;9(2):219-237. doi: 10.1016/j.jcmgh.2019.10.011. Epub 2019 Nov 2.
4
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.GPR109A是一种针对细菌发酵产物丁酸的G蛋白偶联受体，在结肠中发挥肿瘤抑制作用。
Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10.
5
Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.Gpr109a 限制微生物群诱导的 IL-23 产生以限制 ILC3 介导的结肠炎症。
J Immunol. 2018 Apr 15;200(8):2905-2914. doi: 10.4049/jimmunol.1701625. Epub 2018 Mar 7.
6
Autophagy of Intestinal Epithelial Cells Inhibits Colorectal Carcinogenesis Induced by Colibactin-Producing Escherichia coli in Apc Mice.肠上皮细胞自噬抑制产 Colibactin 大肠杆菌诱导的 Apc 小鼠结直肠肿瘤发生。
Gastroenterology. 2020 Apr;158(5):1373-1388. doi: 10.1053/j.gastro.2019.12.026. Epub 2020 Jan 7.
7
Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.丁酸钠以GPR109A依赖的方式减轻断奶仔猪腹泻并促进结肠紧密连接蛋白表达。
Cell Physiol Biochem. 2018;47(4):1617-1629. doi: 10.1159/000490981. Epub 2018 Jun 27.
8
Short-chain free-fatty acid G protein-coupled receptors in colon cancer.结直肠癌中的短链游离脂肪酸 G 蛋白偶联受体。
Biochem Pharmacol. 2021 Apr;186:114483. doi: 10.1016/j.bcp.2021.114483. Epub 2021 Feb 23.
9
Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acid.阐明GPR109A（HM74A）在烟酸临床疗效中的作用。
J Clin Invest. 2005 Dec;115(12):3400-3. doi: 10.1172/JCI27160.
10
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.上皮细胞核因子-κB在炎症性肠病和结肠炎相关癌变中的激活
Digestion. 2016;93(1):40-6. doi: 10.1159/000441670. Epub 2016 Jan 14.
引用本文的文献
1
Analysis of composition of gut microbial community in a rat model of functional dyspepsia treated with Simo Tang.四磨汤治疗功能性消化不良大鼠模型肠道微生物群落组成分析
J Tradit Chin Med. 2024 Dec;44(6):1168-1176. doi: 10.19852/j.cnki.jtcm.20240927.003.
2
Microbiota and Lipotoxicity.微生物群和脂毒性。
Adv Exp Med Biol. 2024;1460:357-372. doi: 10.1007/978-3-031-63657-8_12.
3
BHBA attenuates endoplasmic reticulum stress-dependent neuroinflammation via the gut-brain axis in a mouse model of heat stress.BHBA 通过肠道-大脑轴减轻热应激小鼠模型中内质网应激依赖性神经炎症。
CNS Neurosci Ther. 2024 Jul;30(7):e14840. doi: 10.1111/cns.14840.
4
Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages.化疗诱导的微生物组通过抑制巨噬细胞中的白细胞介素-10 来加剧化疗的毒性。
Gut Microbes. 2024 Jan-Dec;16(1):2319511. doi: 10.1080/19490976.2024.2319511. Epub 2024 Feb 24.
5
Capsules with Ileocolonic-Targeted Release of Vitamin B, B, and C (ColoVit) Intended for Optimization of Gut Health: Development and Validation of the Production Process.用于优化肠道健康的维生素B、B和C回肠结肠靶向释放胶囊（ColoVit）：生产工艺的开发与验证
Pharmaceutics. 2023 Apr 28;15(5):1354. doi: 10.3390/pharmaceutics15051354.
6
Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.微生物组、调节性 T 细胞和 HCA2 之间的串扰调控了小鼠银屑病模型中的炎症反应。
Front Immunol. 2023 Feb 20;14:1038689. doi: 10.3389/fimmu.2023.1038689. eCollection 2023.
7
Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression.肺免疫调节通过肠-肺轴：肠道来源的 LPS 和短链脂肪酸对肺 IL-1β、FFAR2 和 FFAR3 表达的免疫代谢调节。
Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L65-L78. doi: 10.1152/ajplung.00421.2020. Epub 2021 Apr 14.
8
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.烟酰胺和丁酸盐：针对帕金森病中肠道菌群失调和通透性的营养保健品。
Nutrients. 2020 Dec 23;13(1):28. doi: 10.3390/nu13010028.
9
Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?代谢物感应 G 蛋白偶联受体：癌症治疗的有前途的治疗靶点？
Cells. 2020 Oct 23;9(11):2345. doi: 10.3390/cells9112345.
10
Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.高血压的基因组学决定因素研究——重点关注代谢组学和肠道微生物组。
Am J Hypertens. 2020 May 21;33(6):473-481. doi: 10.1093/ajh/hpaa022.
本文引用的文献
1
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.Gpr109a 的激活，作为烟酸和共生代谢物丁酸盐的受体，可抑制结肠炎症和癌变。
Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.
2
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.共生菌产生的代谢物可促进外周调节性 T 细胞的生成。
Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.
3
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.共生微生物衍生的丁酸盐诱导结肠调节性 T 细胞的分化。
Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4
The microbiome and cancer.微生物组与癌症。
Nat Rev Cancer. 2013 Nov;13(11):800-12. doi: 10.1038/nrc3610. Epub 2013 Oct 17.
5
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.微生物代谢产物，短链脂肪酸，调节结肠 Treg 细胞稳态。
Science. 2013 Aug 2;341(6145):569-73. doi: 10.1126/science.1241165. Epub 2013 Jul 4.
6
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.短链脂肪酸激活肠道上皮细胞上的 GPR41 和 GPR43，促进小鼠的炎症反应。
Gastroenterology. 2013 Aug;145(2):396-406.e1-10. doi: 10.1053/j.gastro.2013.04.056. Epub 2013 May 7.
7
Diet, microbiome, and the intestinal epithelium: an essential triumvirate?饮食、微生物组和肠道上皮：一个必不可少的三联体？
Biomed Res Int. 2013;2013:425146. doi: 10.1155/2013/425146. Epub 2013 Mar 17.
8
Host-gut microbiota metabolic interactions.宿主-肠道微生物群代谢相互作用。
Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.
9
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.肠道微生物群的共生菌诱导 Foxp3+ 调节性 T 细胞的发育。
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9. doi: 10.1073/pnas.0909122107. Epub 2010 Jun 21.
10
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.肠道微生物群和趋化因子受体GPR43对炎症反应的调节
Nature. 2009 Oct 29;461(7268):1282-6. doi: 10.1038/nature08530.
Zotero 插件