成年皮肤中的表皮干细胞。
Epithelial stem cells in adult skin.
机构信息
Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, Connecticut, USA.
出版信息
Curr Top Dev Biol. 2014;107:109-31. doi: 10.1016/B978-0-12-416022-4.00004-4.
Abstract
The skin is the first line of defense against dehydration and external environmental aggressions. It constantly renews itself throughout adult life mainly due to the activity of tissue-specific stem cells. In this review, we discuss fundamental characteristics of different stem cell populations within the skin and how they are able to contribute to normal skin homeostasis. We also examine the most recent results regarding the cell-intrinsic and -extrinsic components of the stem cell niche within the adult skin epithelium. Finally, we address the recent efforts to understand how abnormal regulation of stem cell activity contributes to the initiation and progression of skin-associated cancers.
摘要
皮肤是抵御脱水和外部环境侵袭的第一道防线。它在整个成年期内不断更新，主要是由于组织特异性干细胞的活性。在这篇综述中，我们讨论了皮肤内不同干细胞群体的基本特征，以及它们如何有助于维持正常的皮肤内稳态。我们还研究了最近关于成年皮肤上皮内干细胞生态位的细胞内和细胞外成分的结果。最后，我们探讨了最近为了解异常调节干细胞活性如何导致皮肤相关癌症的发生和发展而做出的努力。
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Stem Cell Reports. 2013 Jun 4;1(1):19-27. doi: 10.1016/j.stemcr.2013.04.001. eCollection 2013.
2
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Nat Med. 2013 Jul;19(7):916-23. doi: 10.1038/nm.3181. Epub 2013 Jun 2.
3
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4
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