Department of Animal Developmental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland.
Department of Medical Biochemistry, Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland.
FEBS Lett. 2014 Feb 14;588(4):517-30. doi: 10.1016/j.febslet.2014.01.005. Epub 2014 Jan 17.
Investigations undertaken over the past years have led scientists to introduce the concept of protein quality control (PQC) systems, which are responsible for polypeptide processing. The PQC system monitors proteostasis and involves activity of different chaperones such as small heat shock proteins (sHSPs). These proteins act during normal conditions as housekeeping proteins regulating cellular processes, and during stress conditions. They also mediate the removal of toxic misfolded polypeptides and thereby prevent development of pathogenic states. It is postulated that sHSPs are involved in muscle development. They could act via modulation of myogenesis or by maintenance of the structural integrity of signaling complexes. Moreover, mutations in genes coding for sHSPs lead to pathological states affecting muscular tissue functioning. This review focuses on the question how sHSPs, still relatively poorly understood proteins, contribute to the development and function of three types of muscle tissue: skeletal, cardiac and smooth.
在过去的几年中进行的研究使科学家们提出了蛋白质质量控制 (PQC) 系统的概念，该系统负责多肽加工。PQC 系统监测蛋白质的稳定，并涉及不同伴侣蛋白（如小热休克蛋白 (sHSP)）的活性。这些蛋白质在正常条件下作为管家蛋白调节细胞过程，在应激条件下也发挥作用。它们还介导去除有毒的错误折叠多肽，从而防止致病状态的发展。据推测，sHSP 参与肌肉发育。它们可以通过调节成肌作用或维持信号复合物的结构完整性来发挥作用。此外，编码 sHSP 的基因突变会导致影响肌肉组织功能的病理状态。本综述重点探讨了 sHSPs（仍然是相对了解较少的蛋白质）如何有助于三种类型的肌肉组织（骨骼、心脏和平滑）的发育和功能。
