Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Colloids Surf B Biointerfaces. 2014 Apr 1;116:49-54. doi: 10.1016/j.colsurfb.2013.12.048. Epub 2013 Dec 30.
A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release.
一种新型的具有长间隔基和高胶体稳定性的磁性纳米载体已被制备出来，用于有效递送达氟沙星（DOX）。首先，聚（酰胺-胺）（PAMAM）树枝状大分子被生长到超顺磁性氧化铁纳米粒子的表面上，以增加胺基的载药量。然后，通过聚乙二醇二甲醚对末端胺基进行功能化，以增加间隔基长度。然后，通过腙键将抗癌药物 DOX 共价连接到该系统上，形成 pH 敏感的纳米载体。该系统旨在结合磁靶向、高载药能力和控制释放的优势。
