Withington D E, Leung K B, Bromley L, Scadding G K, Pearce F L
Department of Anaesthesia, St Thomas' Hospital, London.
Anaesthesia. 1987 Aug;42(8):850-4. doi: 10.1111/j.1365-2044.1987.tb04109.x.
A patient who suffered a severe hypotensive episode after induction of anaesthesia, was subsequently found to show positive skin-test responses to suxamethonium. Investigation revealed that suxamethonium induced basophils from the patient to release histamine to an extent comparable to that found after exposure to anit-IgE. Basophils from control subjects showed no such response. Basophil histamine release may offer a useful approach to the investigation of adverse drug reactions.
一名患者在麻醉诱导后发生严重低血压事件，随后发现其对琥珀胆碱的皮肤试验反应呈阳性。调查显示，琥珀胆碱诱导该患者的嗜碱性粒细胞释放组胺的程度与接触抗IgE后相当。对照受试者的嗜碱性粒细胞未显示出此类反应。嗜碱性粒细胞组胺释放可能为药物不良反应的调查提供一种有用的方法。
