Withington D E
Chemistry Department, University College London, UK.
Agents Actions. 1988 Apr;23(3-4):337-8. doi: 10.1007/BF02142581.
Propofol (2,6-diisopropylphenol) has recently been introduced into clinical practice as an induction agent. This study evaluated the effect of propofol on basophil histamine release in 13 healthy subjects. No release was demonstrated in 11 subjects. Two subjects released histamine at the highest drug concentration, one also releasing at lower concentrations. Both subjects whose basophils released histamine in response to propofol were anaesthetists using the drug during the course of their practice.
丙泊酚（2,6 - 二异丙基苯酚）最近已作为一种诱导剂引入临床实践。本研究评估了丙泊酚对13名健康受试者嗜碱性粒细胞组胺释放的影响。11名受试者未出现组胺释放。两名受试者在最高药物浓度时释放组胺，其中一名在较低浓度时也有释放。嗜碱性粒细胞对丙泊酚释放组胺的两名受试者在其执业过程中均为使用该药物的麻醉医生。
