Cheung P T, Low L C
Department of Paediatrics, University of Hong Kong.
Aust Paediatr J. 1987 Jun;23(3):201-3. doi: 10.1111/j.1440-1754.1987.tb00246.x.
A boy aged 7.5 years presented with precocious onset of secondary sexual characteristics and symptoms and signs of neurological dysfunction. A CT brain scan demonstrated a suprasellar mass lesion. The elevated beta-hCG and alpha-fetoprotein concentrations in cerebrospinal fluid and in serum were consistent with a diagnosis of intracranial embryonal carcinoma, although histological diagnosis was not available. The tumour markers beta-hCG and alpha-FP should be looked for in all children with precocious puberty presenting with midline brain tumours.
