Howlett T A, el-Senoussi M, Fox J L, Woodhouse N J
Horm Res. 1987;25(1):13-7. doi: 10.1159/000180627.
A 14 year-old boy presented with visual impairment due to a large suprasellar tumour secreting beta-human chorionic gonadotrophin (BhCG) and alpha-fetoprotein (alpha FP). He was sexually mature with an advanced bone age of 17 years, and suffering from partial hypopituitarism. Treatment with external radiotherapy resulted in a reduction of tumour size and fall of the serum testosterone BhCG and alpha FP levels. We conclude that pubertal development had been initiated and maintained by ectopic hCG production from his intracerebral mixed germ cell tumour. Patients with tumours in the pineal and suprasellar regions should be screened for elevated levels of BhCG and alpha FP. We suspect that many of these tumours cause precocious puberty by secreting BhCG.
一名14岁男孩因鞍上巨大肿瘤分泌β-人绒毛膜促性腺激素（BhCG）和甲胎蛋白（αFP）而出现视力障碍。他性成熟，骨龄提前至17岁，且患有部分垂体功能减退。外照射放疗导致肿瘤体积缩小，血清睾酮、BhCG和αFP水平下降。我们得出结论，青春期发育是由其脑内混合性生殖细胞瘤异位产生的hCG启动并维持的。松果体区和鞍上区肿瘤患者应筛查BhCG和αFP水平升高情况。我们怀疑这些肿瘤中有许多通过分泌BhCG导致性早熟。
