缺血后单胺氧化酶的轴浆运输

Axoplasmic transport of monoamine oxidase after ischemia.

作者信息

Chavko M, Helemiková A, Marsala J

机构信息

Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Czechoslovakia.

出版信息

Exp Neurol. 1987 Nov;98(2):205-11. doi: 10.1016/0014-4886(87)90236-6.

DOI:10.1016/0014-4886(87)90236-6

PMID:2444448

Abstract

Rabbit spinal cords were subjected to 40 min of ischemia by abdominal aorta occlusion followed by 1 or 4 days of recirculation. Axoplasmic transport of mitochondria was investigated by monitoring the accumulation of monoamine oxidase activity (MAO, EC 1.4.3.4) at the proximal and distal ligatures placed on sciatic nerves. Within 1 day following ischemia, MAO accumulation was reduced to 45% and 34% at the proximal and distal ties, respectively. Within 4 days after ischemia, MAO accumulation was depressed still further to 22% in either direction. The substantial decrease in transport velocity appears to be the immediate cause for the observed decrease in MAO accumulation in sciatic nerve.

摘要

通过腹主动脉阻断使兔脊髓缺血40分钟，随后再灌注1天或4天。通过监测坐骨神经近端和远端结扎处单胺氧化酶活性（MAO，EC 1.4.3.4）的积累来研究线粒体的轴浆运输。缺血后1天内，近端和远端结扎处的MAO积累分别降至45%和34%。缺血后4天内，两个方向的MAO积累进一步降至22%。运输速度的大幅下降似乎是观察到的坐骨神经中MAO积累减少的直接原因。