头孢他啶或拉氧头孢是否会影响人类粒细胞的吞噬能力？
Does ceftazidime or latamoxef affect the phagocytic capabilities of human granulocytes?
作者信息
Prokopowicz J, Dabrowska M, Wysocka J, Wołosowicz N, Gabryelewicz A
机构信息
Department of Laboratory Clinical Diagnostics, Medical School, Białystok, Poland.
出版信息
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(3):390-7.
In comparative studies made in patients with pneumonia we have treated 14 cases with Latamoxef and 16 cases with Ceftazidime. We have focused attention on the side effects of these drugs and on the phagocytic capacity of granulocytes. In our patients we have noted a decrease of bactericidal activity of plasma and granulocytes and an elevated NBT reduction capability of resting granulocytes. The other tested function of the granulocytes exhibited only small variations. The applied therapy caused the bactericidal activity to be increased in granulocytes and plasma. Both drugs had no harmful effect on the phagocytic activities of granulocytes.
在对肺炎患者进行的比较研究中，我们用拉氧头孢治疗了14例患者，用头孢他啶治疗了16例患者。我们重点关注了这些药物的副作用以及粒细胞的吞噬能力。在我们的患者中，我们注意到血浆和粒细胞的杀菌活性降低，静息粒细胞的NBT还原能力升高。粒细胞的其他测试功能仅表现出微小变化。所应用的治疗使粒细胞和血浆中的杀菌活性增加。两种药物对粒细胞的吞噬活性均无有害影响。
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