Gabryelewicz A, Prokopowicz J, Wołosowicz N, Czajkowski A, Dabrowska M
Department of Gastroenterology, Medical School, Białystok, Poland.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(3):398-407.
In comparative studies made in patients with pneumonia we have treated 14 cases with Latamoxef and 16 cases with Ceftazidime. We have concentrated our attention on the side effects of these drugs on hemostasis. In 8 patients treated with Latamoxef we have found a prolongation bleeding time, moderate hypoprothrombinemia, thrombocytopenia and nearly no normalization of APTT and plasma euglobulin fibrinolysis. In one patient treated with Ceftazidime only slight effect of this drug on hemostasis was observed. Crucial reason for coagulopathy is probably due to impaired synthesis of vitamin K by diminished gut flora conditioned by antibiotics treatment. In the case of Ceftazidime mentioned there seem to be minimal side effects.
在针对肺炎患者进行的对比研究中，我们用拉氧头孢治疗了14例患者，用头孢他啶治疗了16例患者。我们重点关注了这些药物对止血功能的副作用。在用拉氧头孢治疗的8例患者中，我们发现出血时间延长、中度低凝血酶原血症、血小板减少，且活化部分凝血活酶时间（APTT）和血浆优球蛋白溶解几乎没有恢复正常。在用头孢他啶治疗的1例患者中，仅观察到该药物对止血功能有轻微影响。凝血病的关键原因可能是抗生素治疗导致肠道菌群减少，从而使维生素K合成受损。在上述提到的头孢他啶病例中，似乎副作用极小。
