Thorek Daniel L J, Ulmert David, Diop Ndeye-Fatou M, Lupu Mihaela E, Doran Michael G, Huang Ruimin, Abou Diane S, Larson Steven M, Grimm Jan
1] Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins School of Medicine, 601 N. Caroline Street, JHOC 3223, Baltimore, Maryland 21287, USA [2] Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA.
1] Department of Surgery, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA [2] Department of Urology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
Nat Commun. 2014;5:3097. doi: 10.1038/ncomms4097.
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.
肿瘤引流淋巴结（LNs）的浸润状态是癌症分期的关键指标，对治疗方案的制定至关重要。目前，临床医生使用平面闪烁扫描和单光子发射计算机断层扫描（SPECT）结合（99m）锝放射性胶体来指导淋巴结的活检和切除。然而，正电子发射断层扫描结合磁共振成像（PET/MRI）等新兴的多模态方法在检测疾病部位时具有更高的灵敏度和准确性。在此，我们展示了一种多模态纳米颗粒（89）Zr-铁氧还蛋白，用于通过PET/MRI增强对淋巴结的检测。为了具有真正的转化潜力，我们利用一种临床氧化铁制剂，只需进行最小程度的修饰即可用于放射性标记。我们研究了未接触过抗原的小鼠以及健康和荷瘤前列腺的腋窝引流情况。我们证明，（89）Zr-铁氧还蛋白可用于临床前疾病模型中淋巴引流的高分辨率断层扫描研究。这个纳米颗粒平台在改善淋巴结切除术前规划和肿瘤分期方面具有显著的转化潜力。
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