Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
J Nucl Med. 2013 Apr;54(4):585-9. doi: 10.2967/jnumed.112.115188. Epub 2013 Feb 1.
With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs.
In this study, the clinical feasibility of PET/CT lymphoscintigraphy using (89)Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of (89)Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using (99m)Tc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of (89)Zr-nanocolloidal albumin.
Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/CT was able to identify additional foci near the primary tumor.
This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using (89)Zr-nanocolloidal albumin is feasible.
在使用平面淋巴闪烁显像和 SPECT/CT 等常规成像技术时，当前哨淋巴结 (SN) 靠近原发性肿瘤时，例如在口腔底部癌中，SN 的术前识别可能会很困难。PET/CT 淋巴闪烁显像可能会提高这些 SN 的检测和定位能力。
在这项研究中，我们评估了使用 (89)Zr-纳米胶体白蛋白进行 PET/CT 淋巴闪烁显像在 5 例口腔癌患者中的临床可行性。在肿瘤周围注射 (89)Zr-纳米胶体白蛋白后进行 PET/CT 淋巴闪烁显像。在注射 (89)Zr-纳米胶体白蛋白 7-9 天后，对同一患者进行常规 SN 程序，包括使用 (99m)Tc-纳米胶体白蛋白进行 SPECT/CT。
比较 PET/CT 和 SPECT/CT 上放射性胶体的分布显示出相同的引流模式。此外，PET/CT 还能够在原发性肿瘤附近识别出其他焦点。
这项关于 SN 检测的 PET/CT 初步研究表明，使用 (89)Zr-纳米胶体进行淋巴闪烁显像是可行的。
