药物性暴发性肝炎在儿童中发生，该儿童正在接受潜伏性耐多药结核病的双重治疗，联合使用吡嗪酰胺和左氧氟沙星。

Drug-Induced Fulminant Hepatitis in a Child Treated for Latent Multidrug-Resistant Tuberculosis With Dual Therapy Combining Pyrazinamide and Levofloxacin.

机构信息

From the Service d'Urgences et de Réanimation Pédiatrique, Hôpital Femme-Mère-Enfant, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.

Service des maladies infectieuses, Hôpital de la Croix Rousse, Groupement Hospitaliser Nord, Hospices Civils de Lyon, Université Claude Bernard Lyon, Lyon, France.

出版信息

Pediatr Infect Dis J. 2019 Oct;38(10):1025-1026. doi: 10.1097/INF.0000000000002413.

DOI:10.1097/INF.0000000000002413

PMID:31335574

Abstract

We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.

摘要

我们报告了一例 10 岁儿童因接触涂片阳性耐多药肺结核成人后，接受吡嗪酰胺（PZA）和左氧氟沙星治疗潜伏性结核感染（LTBI）的病例。在治疗过程中，患者发生了由 PZA 和左氧氟沙星联合使用引起的药物性暴发性肝炎。该病例强调了儿童二线抗结核治疗联合用药的肝毒性。