Department of Chemistry, University of Houston, 112 Fleming Building, Houston, TX 77204-5003, USA.
Chem Soc Rev. 2014 Mar 21;43(6):1873-84. doi: 10.1039/c3cs60356c.
Dynamic combinatorial libraries (DCLs) are collections of structurally related compounds that can interconvert through reversible chemical reaction(s). Such reversibility endows DCLs with adaptability to external stimuli, as rapid interconversion allows quick expression of those DCL components which best respond to the disturbing stimulus. This Tutorial Review focuses on the kinetically controlled phenomena that occur within DCLs. Specifically, it will describe dynamic chiral resolution of DCLs, their self-sorting under the influence of irreversible chemical and physical stimuli, and the autocatalytic behaviours within DCLs which can result in self-replicating systems. A brief discussion of precipitation-induced phenomena will follow and the review will conclude with the presentation of covalent organic frameworks (COFs)-porous materials whose synthesis critically depends on the fine tuning of the crystal growth and error correction rates within large DCLs.
动态组合化学库（DCL）是结构相关化合物的集合，它们可以通过可逆化学反应相互转化。这种可逆性使 DCL 具有对外界刺激的适应性，因为快速的相互转化可以快速表达那些对干扰刺激反应最好的 DCL 成分。本教程综述重点介绍了 DCL 内部发生的动力学控制现象。具体来说，它将描述 DCL 的动态手性拆分、在不可逆化学和物理刺激下的自分类，以及 DCL 内部的自催化行为，这些行为可能导致自我复制系统。接下来将简要讨论沉淀诱导现象，最后介绍共价有机骨架（COF）-多孔材料，其合成严重依赖于对大 DCL 中晶体生长和纠错率的精细调整。
