在健康学生中，开始使用大麻时的拟精神病效应与大麻素受体1（CNR1）变体有关。 - Suppr

Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

作者信息

Krebs M O, Morvan Y, Jay T, Gaillard R, Kebir O

机构信息

1] Université Paris Descartes; PRES Paris Sorbonne Cité; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR 894, Paris, France [2] Hôpital Sainte-Anne, Service Hospitalo-Universitaire, Faculté de Médecine Paris Descartes, Paris, France [3] GDR3557-Institut de Psychiatrie, Paris, France.

1] Université Paris Descartes; PRES Paris Sorbonne Cité; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR 894, Paris, France [2] Laboratoire Cognition, Santé, Socialisation, C2S, EA6291, Université de Reims Champagne-Ardenne, Reims, France [3] GDR3557-Institut de Psychiatrie, Paris, France.

出版信息

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

DOI:10.1038/mp.2013.188

PMID:24445906

Abstract

摘要

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Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior.

Neuropsychopharmacology. 2015 Feb;40(3):640-9. doi: 10.1038/npp.2014.213. Epub 2014 Aug 20.

Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.

Am J Drug Alcohol Abuse. 2016 Jul;42(4):431-40. doi: 10.3109/00952990.2016.1141913. Epub 2016 Apr 13.

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):736-40. doi: 10.1002/ajmg.b.30881.

Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis.

Int J Mol Sci. 2021 Jul 9;22(14):7388. doi: 10.3390/ijms22147388.

and variation and affective states induced by marijuana smoking.

Am J Drug Alcohol Abuse. 2019;45(5):514-526. doi: 10.1080/00952990.2019.1614596. Epub 2019 Jun 11.

Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene.

Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):97-103. doi: 10.1002/ajmg.b.20159.

Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.

J Stud Alcohol Drugs. 2013 Nov;74(6):867-78. doi: 10.15288/jsad.2013.74.867.

Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.

Neurosci Lett. 2011 May 27;496(1):60-4. doi: 10.1016/j.neulet.2011.04.003. Epub 2011 Apr 12.

Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

Schizophr Res. 2011 May;128(1-3):66-75. doi: 10.1016/j.schres.2011.02.021. Epub 2011 Mar 21.

引用本文的文献

Rates and correlates of cannabis-associated psychotic symptoms in over 230,000 people who use cannabis.

Transl Psychiatry. 2022 Sep 6;12(1):369. doi: 10.1038/s41398-022-02112-8.

Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls.

Braz J Psychiatry. 2022 Jan-Feb;44(1):26-34. doi: 10.1590/1516-4446-2020-1650.

The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.

Braz J Psychiatry. 2017 Apr-Jun;39(2):160-171. doi: 10.1590/1516-4446-2016-1969. Epub 2017 Jan 12.

Genetic and Environmental Factors Associated with Cannabis Involvement.

Curr Addict Rep. 2016 Jun;3(2):199-213. doi: 10.1007/s40429-016-0103-1. Epub 2016 Apr 12.

Long-term consequences of adolescent cannabinoid exposure in adult psychopathology.

Front Neurosci. 2014 Nov 10;8:361. doi: 10.3389/fnins.2014.00361. eCollection 2014.

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Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

Biol Psychiatry. 2012 Nov 15;72(10):811-6. doi: 10.1016/j.biopsych.2012.06.020. Epub 2012 Jul 24.

Gene-environment interactions underlying the effect of cannabis in first episode psychosis.

Curr Pharm Des. 2012;18(32):5024-35. doi: 10.2174/138161212802884609.

Genetic variation underlying psychosis-inducing effects of cannabis: critical review and future directions.

Curr Pharm Des. 2012;18(32):5015-23. doi: 10.2174/138161212802884591.

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus.

J Biol Chem. 2012 Apr 13;287(16):12828-34. doi: 10.1074/jbc.M111.336750. Epub 2012 Feb 23.

Cannabis, COMT and psychotic experiences.

Br J Psychiatry. 2011 Nov;199(5):380-5. doi: 10.1192/bjp.bp.111.091421. Epub 2011 Sep 22.

CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.

Neuropsychopharmacology. 2009 Jul;34(8):2019-27. doi: 10.1038/npp.2009.19. Epub 2009 Feb 25.

The incentive salience of alcohol: translating the effects of genetic variant in CNR1.

Arch Gen Psychiatry. 2008 Jul;65(7):841-50. doi: 10.1001/archpsyc.65.7.841.

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.

Lancet. 2007 Jul 28;370(9584):319-28. doi: 10.1016/S0140-6736(07)61162-3.

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.

Biol Psychiatry. 2005 May 15;57(10):1117-27. doi: 10.1016/j.biopsych.2005.01.026.

Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.

Mol Psychiatry. 2004 Oct;9(10):916-31. doi: 10.1038/sj.mp.4001560.

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Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

作者信息

Krebs M O, Morvan Y, Jay T, Gaillard R, Kebir O

机构信息

1] Université Paris Descartes; PRES Paris Sorbonne Cité; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR 894, Paris, France [2] Laboratoire Cognition, Santé, Socialisation, C2S, EA6291, Université de Reims Champagne-Ardenne, Reims, France [3] GDR3557-Institut de Psychiatrie, Paris, France.

出版信息

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

DOI:10.1038/mp.2013.188

PMID:24445906

Abstract

摘要

相似文献

Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior.

Neuropsychopharmacology. 2015 Feb;40(3):640-9. doi: 10.1038/npp.2014.213. Epub 2014 Aug 20.

Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.

Am J Drug Alcohol Abuse. 2016 Jul;42(4):431-40. doi: 10.3109/00952990.2016.1141913. Epub 2016 Apr 13.

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):736-40. doi: 10.1002/ajmg.b.30881.

Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis.

Int J Mol Sci. 2021 Jul 9;22(14):7388. doi: 10.3390/ijms22147388.

and variation and affective states induced by marijuana smoking.

Am J Drug Alcohol Abuse. 2019;45(5):514-526. doi: 10.1080/00952990.2019.1614596. Epub 2019 Jun 11.

Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene.

Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):97-103. doi: 10.1002/ajmg.b.20159.

Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.

J Stud Alcohol Drugs. 2013 Nov;74(6):867-78. doi: 10.15288/jsad.2013.74.867.

Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.

Neurosci Lett. 2011 May 27;496(1):60-4. doi: 10.1016/j.neulet.2011.04.003. Epub 2011 Apr 12.

Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

Schizophr Res. 2011 May;128(1-3):66-75. doi: 10.1016/j.schres.2011.02.021. Epub 2011 Mar 21.

引用本文的文献

Rates and correlates of cannabis-associated psychotic symptoms in over 230,000 people who use cannabis.

Transl Psychiatry. 2022 Sep 6;12(1):369. doi: 10.1038/s41398-022-02112-8.

Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls.

Braz J Psychiatry. 2022 Jan-Feb;44(1):26-34. doi: 10.1590/1516-4446-2020-1650.

The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.

Braz J Psychiatry. 2017 Apr-Jun;39(2):160-171. doi: 10.1590/1516-4446-2016-1969. Epub 2017 Jan 12.

Genetic and Environmental Factors Associated with Cannabis Involvement.

Curr Addict Rep. 2016 Jun;3(2):199-213. doi: 10.1007/s40429-016-0103-1. Epub 2016 Apr 12.

Long-term consequences of adolescent cannabinoid exposure in adult psychopathology.

Front Neurosci. 2014 Nov 10;8:361. doi: 10.3389/fnins.2014.00361. eCollection 2014.

本文引用的文献

Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

Biol Psychiatry. 2012 Nov 15;72(10):811-6. doi: 10.1016/j.biopsych.2012.06.020. Epub 2012 Jul 24.

Gene-environment interactions underlying the effect of cannabis in first episode psychosis.

Curr Pharm Des. 2012;18(32):5024-35. doi: 10.2174/138161212802884609.

Genetic variation underlying psychosis-inducing effects of cannabis: critical review and future directions.

Curr Pharm Des. 2012;18(32):5015-23. doi: 10.2174/138161212802884591.

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus.

J Biol Chem. 2012 Apr 13;287(16):12828-34. doi: 10.1074/jbc.M111.336750. Epub 2012 Feb 23.

Cannabis, COMT and psychotic experiences.

Br J Psychiatry. 2011 Nov;199(5):380-5. doi: 10.1192/bjp.bp.111.091421. Epub 2011 Sep 22.

CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.

Neuropsychopharmacology. 2009 Jul;34(8):2019-27. doi: 10.1038/npp.2009.19. Epub 2009 Feb 25.

The incentive salience of alcohol: translating the effects of genetic variant in CNR1.

Arch Gen Psychiatry. 2008 Jul;65(7):841-50. doi: 10.1001/archpsyc.65.7.841.

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.

Lancet. 2007 Jul 28;370(9584):319-28. doi: 10.1016/S0140-6736(07)61162-3.

Biol Psychiatry. 2005 May 15;57(10):1117-27. doi: 10.1016/j.biopsych.2005.01.026.

Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.

Mol Psychiatry. 2004 Oct;9(10):916-31. doi: 10.1038/sj.mp.4001560.

Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

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Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

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