在健康学生中，开始使用大麻时的拟精神病效应与大麻素受体1（CNR1）变体有关。 - Suppr

Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

作者信息

Krebs M O, Morvan Y, Jay T, Gaillard R, Kebir O

机构信息

1] Université Paris Descartes; PRES Paris Sorbonne Cité; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR 894, Paris, France [2] Hôpital Sainte-Anne, Service Hospitalo-Universitaire, Faculté de Médecine Paris Descartes, Paris, France [3] GDR3557-Institut de Psychiatrie, Paris, France.

1] Université Paris Descartes; PRES Paris Sorbonne Cité; INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR 894, Paris, France [2] Laboratoire Cognition, Santé, Socialisation, C2S, EA6291, Université de Reims Champagne-Ardenne, Reims, France [3] GDR3557-Institut de Psychiatrie, Paris, France.

出版信息

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

DOI:10.1038/mp.2013.188

PMID:24445906

Abstract

摘要

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Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.在健康学生中，开始使用大麻时的拟精神病效应与大麻素受体1（CNR1）变体有关。

Mol Psychiatry. 2014 Apr;19(4):402-3. doi: 10.1038/mp.2013.188. Epub 2014 Jan 21.

Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior.大麻素受体1的功能基因变异与大麻使用在前额叶连接性及相关工作记忆行为上存在相互作用。

Neuropsychopharmacology. 2015 Feb;40(3):640-9. doi: 10.1038/npp.2014.213. Epub 2014 Aug 20.

Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.剂量依赖性大麻使用、抑郁症状和脂肪酸酰胺水解酶（FAAH）基因型预测青少年的睡眠质量：一项初步研究。

Am J Drug Alcohol Abuse. 2016 Jul;42(4):431-40. doi: 10.3109/00952990.2016.1141913. Epub 2016 Apr 13.

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.大麻素受体1（CNR1）基因多态性与大麻依赖之间关联的证据。

Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):736-40. doi: 10.1002/ajmg.b.30881.

Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis.大麻素受体 1 基因变异对吸食大麻主观效应的影响。

Int J Mol Sci. 2021 Jul 9;22(14):7388. doi: 10.3390/ijms22147388.

and variation and affective states induced by marijuana smoking.并且大麻吸烟引起的变异和情感状态。

Am J Drug Alcohol Abuse. 2019;45(5):514-526. doi: 10.1080/00952990.2019.1614596. Epub 2019 Jun 11.

Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene.

Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):97-103. doi: 10.1002/ajmg.b.20159.

Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.冲动性、大麻素受体（CNR1）和脂肪酸酰胺水解酶（FAAH）基因的变异以及与大麻相关的问题。

J Stud Alcohol Drugs. 2013 Nov;74(6):867-78. doi: 10.15288/jsad.2013.74.867.

Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.大麻素受体基因（CNR1）多态性与大麻素诱导的听觉事件相关 P300 电位变化的关联。

Neurosci Lett. 2011 May 27;496(1):60-4. doi: 10.1016/j.neulet.2011.04.003. Epub 2011 Apr 12.

Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.大麻素受体 1 基因多态性与大麻滥用对精神分裂症患者脑白质和认知功能障碍的交互作用。

Schizophr Res. 2011 May;128(1-3):66-75. doi: 10.1016/j.schres.2011.02.021. Epub 2011 Mar 21.

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Rates and correlates of cannabis-associated psychotic symptoms in over 230,000 people who use cannabis.在超过 23 万名使用大麻的人群中，大麻相关精神病症状的发生率和相关因素。

Transl Psychiatry. 2022 Sep 6;12(1):369. doi: 10.1038/s41398-022-02112-8.

Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls.大麻素受体基因多态性与精神分裂症患者和对照组认知表现的关系。

Braz J Psychiatry. 2022 Jan-Feb;44(1):26-34. doi: 10.1590/1516-4446-2020-1650.

The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data.CNR1基因在精神分裂症中的作用：一项包括未发表数据的系统综述

Braz J Psychiatry. 2017 Apr-Jun;39(2):160-171. doi: 10.1590/1516-4446-2016-1969. Epub 2017 Jan 12.

Genetic and Environmental Factors Associated with Cannabis Involvement.与大麻使用相关的遗传和环境因素。

Curr Addict Rep. 2016 Jun;3(2):199-213. doi: 10.1007/s40429-016-0103-1. Epub 2016 Apr 12.

Long-term consequences of adolescent cannabinoid exposure in adult psychopathology.青少年期大麻素暴露对成年精神病理学的长期影响。

Front Neurosci. 2014 Nov 10;8:361. doi: 10.3389/fnins.2014.00361. eCollection 2014.

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Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.确认 AKT1(rs2494732) 基因型影响使用大麻者患精神病的风险。

Biol Psychiatry. 2012 Nov 15;72(10):811-6. doi: 10.1016/j.biopsych.2012.06.020. Epub 2012 Jul 24.

Gene-environment interactions underlying the effect of cannabis in first episode psychosis.大麻对首发精神病影响的基因-环境相互作用。

Curr Pharm Des. 2012;18(32):5024-35. doi: 10.2174/138161212802884609.

Genetic variation underlying psychosis-inducing effects of cannabis: critical review and future directions.精神分裂症诱导型大麻的遗传变异基础：批判性回顾和未来方向。

Curr Pharm Des. 2012;18(32):5015-23. doi: 10.2174/138161212802884591.

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus.新型大麻素受体 1（CNR1）基因内含子增强子在下丘脑、背根神经节和海马体中活性的等位基因特异性差异。

J Biol Chem. 2012 Apr 13;287(16):12828-34. doi: 10.1074/jbc.M111.336750. Epub 2012 Feb 23.

Cannabis, COMT and psychotic experiences.大麻、儿茶酚-O-甲基转移酶与精神病性体验。

Br J Psychiatry. 2011 Nov;199(5):380-5. doi: 10.1192/bjp.bp.111.091421. Epub 2011 Sep 22.

CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.CNR1基因与高神经质和低宜人性相关，并与近期的负面生活事件相互作用，以预测当前的抑郁症状。

Neuropsychopharmacology. 2009 Jul;34(8):2019-27. doi: 10.1038/npp.2009.19. Epub 2009 Feb 25.

The incentive salience of alcohol: translating the effects of genetic variant in CNR1.酒精的动机显著性：解读CNR1基因变异的影响

Arch Gen Psychiatry. 2008 Jul;65(7):841-50. doi: 10.1001/archpsyc.65.7.841.

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.大麻使用与精神性或情感性心理健康结局风险：一项系统评价

Lancet. 2007 Jul 28;370(9584):319-28. doi: 10.1016/S0140-6736(07)61162-3.

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.儿茶酚-O-甲基转移酶基因功能多态性对青少年期开始使用大麻所致成人精神病效应的调节作用：基因X环境相互作用的纵向证据

Biol Psychiatry. 2005 May 15;57(10):1117-27. doi: 10.1016/j.biopsych.2005.01.026.

Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.人类大麻素受体1：5'外显子、候选调控区域、多态性、单倍型以及与多种物质滥用的关联

Mol Psychiatry. 2004 Oct;9(10):916-31. doi: 10.1038/sj.mp.4001560.

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Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students.

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