Center for Cognitive Science, Department of Psychology, and.
Philos Trans R Soc Lond B Biol Sci. 2014 Jan 20;369(1637):20120464. doi: 10.1098/rstb.2012.0464. Print 2014 Mar 5.
We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.
我们使用全自动系统来测量认知基本机制的生理相关特性，以测试两种杂合突变体小鼠（Bfc 和 L1）及其野生型同窝对照，这两种靶基因都参与了突触的建立和维持。我们发现 Bfc 杂合子在表示时间间隔的精度上降低，而 L1 杂合子则表现出更高的精度。这些影响具有功能特异性，因为在同一批小鼠上进行的许多其他测量结果都不受影响，即：在匹配协议中，将时间投资比率与收入比率相匹配的准确性、工具性和经典条件反射的速度、启动线索性工具性反应的潜伏期、在任务上的尝试次数以及在切换范式中的冲动性、调整时间切换以适应时间约束变化的准确性、获得的天数以及在食物供应的时间预期中，起始时间和起始可变性的平均值。
