Department of Chemistry, University of Massachusetts , Amherst, Massachusetts 01003, United States.
J Am Chem Soc. 2014 Feb 12;136(6):2220-3. doi: 10.1021/ja4108676. Epub 2014 Jan 29.
An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.
设计了一种两亲性纳米组装体以响应蛋白质和酶的同时存在。我们在此介绍了一种系统，其中在存在这两种刺激物的情况下会发生超分子解体和分子释放。这种分子释放以荧光响应的形式出现，已被证明具有特异性。我们还表明，可以对该系统进行修改，以使仅在存在光刺激以及蛋白质和酶的情况下才做出响应。这种超分子分解原理的证明可能在各种生物应用中具有广泛的意义。
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