Gao Jingjing, Liu Xiaochi, Secinti Hatice, Jiang Ziwen, Munkhbat Oyuntuya, Xu Yisheng, Guo Xuhong, Thayumanavan S
Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Chemistry. 2018 Feb 6;24(8):1789-1794. doi: 10.1002/chem.201705217. Epub 2018 Jan 16.
Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New molecular designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics.
对两种不同输入同时存在的特异性响应是自然界中纳入特异性的标志之一。能够同时对两种截然不同的输入做出响应的人工纳米组装体在各种应用中，尤其是在生物医学领域，具有极大的吸引力。在此，我们提出了一种具有这种能力的两亲性纳米组装体的设计策略，该策略通过光笼蔽一种能够与特定蛋白质结合的配体部分来实现。概述了新的分子设计，这些设计提供了对两种输入中的任何一种或仅对两种输入同时存在做出响应的纳米组装体。这种仿生纳米组装体可用于许多应用，包括药物递送和诊断。
