通过光化学交联控制酶敏感的两亲性树枝状聚合物纳米粒子的释放。
Guest-release control in enzyme-sensitive, amphiphilic-dendrimer-based nanoparticles through photochemical crosslinking.
机构信息
Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Chemistry. 2011 Oct 10;17(42):11752-60. doi: 10.1002/chem.201101066. Epub 2011 Sep 2.
Abstract
Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme-responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non-covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo-crosslinking is also utilized as a tool to investigate the mode of enzyme-substrate interaction in the context of aggregate-monomer equilibrium.
摘要
刺激响应型两亲性树枝状聚合物的合成及其酶响应特性已通过共价连接和非共价结合的报告基团的双重荧光响应来确定。这两种响应相关联，以确定酶促作用对胶束聚集的影响以及随后的客体分子释放。通过光化学交联疏水性香豆素单元来稳定胶束聚集，从而方便地调节客体分子的释放。这种光交联也被用作工具来研究在聚集态-单体平衡的背景下酶-底物相互作用的模式。
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本文引用的文献
1
Helix self-assembly through the coiling of cylindrical micelles.
Soft Matter. 2007 Dec 11;4(1):90-93. doi: 10.1039/b715459c.
2
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672.
3
A fluorophore ligase for site-specific protein labeling inside living cells.
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10914-9. doi: 10.1073/pnas.0914067107. Epub 2010 Jun 7.
4
Facile, template-free synthesis of stimuli-responsive polymer nanocapsules for targeted drug delivery.
Angew Chem Int Ed Engl. 2010 Jun 14;49(26):4405-8. doi: 10.1002/anie.201000818.
5
Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine.
Chem Rev. 2010 Apr 14;110(4):1857-959. doi: 10.1021/cr900327d.
6
Disassembly of dendritic micellar containers due to protein binding.
J Am Chem Soc. 2010 Apr 7;132(13):4550-1. doi: 10.1021/ja100746d.
7
Redox, Ionic Strength, and pH Sensitive Supramolecular Polymer Assemblies.
J Polym Sci A Polym Chem. 2009 Jan 8;47(4):1052-1060. doi: 10.1002/pola.23204.
8
Light-responsive biomaterials: development and applications.
Macromol Biosci. 2010 Apr 8;10(4):339-48. doi: 10.1002/mabi.200900297.
9
Site-specific installation and study of electroactive units in every layer of dendrons.
J Org Chem. 2009 Dec 18;74(24):9475-85. doi: 10.1021/jo902109u.
10
Enzyme-triggered disassembly of dendrimer-based amphiphilic nanocontainers.
J Am Chem Soc. 2009 Oct 14;131(40):14184-5. doi: 10.1021/ja906162u.
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