通过光化学交联控制酶敏感的两亲性树枝状聚合物纳米粒子的释放。
Guest-release control in enzyme-sensitive, amphiphilic-dendrimer-based nanoparticles through photochemical crosslinking.
机构信息
Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Chemistry. 2011 Oct 10;17(42):11752-60. doi: 10.1002/chem.201101066. Epub 2011 Sep 2.
Abstract
Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme-responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non-covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo-crosslinking is also utilized as a tool to investigate the mode of enzyme-substrate interaction in the context of aggregate-monomer equilibrium.
摘要
刺激响应型两亲性树枝状聚合物的合成及其酶响应特性已通过共价连接和非共价结合的报告基团的双重荧光响应来确定。这两种响应相关联，以确定酶促作用对胶束聚集的影响以及随后的客体分子释放。通过光化学交联疏水性香豆素单元来稳定胶束聚集，从而方便地调节客体分子的释放。这种光交联也被用作工具来研究在聚集态-单体平衡的背景下酶-底物相互作用的模式。
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