School of Public Health.
Center for Interdisciplinary Research on AIDS, Yale University.
Health Psychol. 2014 Sep;33(9):1033-45. doi: 10.1037/a0034586. Epub 2014 Jan 20.
There is evidence that pregnancy-specific stress is associated with preterm birth. The purpose of this study is to examine the association between change in pregnancy-specific stress over the course of pregnancy and birth outcomes (i.e., preterm birth and gestational age) in an understudied but vulnerable group using a theoretically derived model.
Multivariate linear and logistic regression techniques were used to examine the association between pregnancy-specific stress (measured in second and third trimester) and length of gestation (i.e., preterm birth and gestational age) among a sample of 920 Black and/or Latina adolescent and young women.
Second trimester pregnancy-specific stress was not associated with preterm birth or gestational age. Third trimester pregnancy-specific stress was associated with preterm birth but not with gestational age. Change in pregnancy-specific stress between second and third trimester was significantly associated with increased likelihood of preterm delivery and shortened gestational age, even after controlling for important biological, behavioral, psychological, interpersonal, and sociocultural risk factors.
Findings emphasize the importance of measuring pregnancy-specific stress across pregnancy, as the longitudinal change from second to third trimester was significantly associated with length of gestation measured both as a dichotomous variable (preterm birth) and a continuous variable (gestational age). Furthermore, this is the first study to observe the association of pregnancy-specific stress with length of gestation in this understudied population-unique in age, race, and ethnicity.
有证据表明,妊娠特异性应激与早产有关。本研究旨在使用理论推导模型,在一个研究不足但脆弱的群体中,检查妊娠特异性应激在整个孕期的变化与出生结局(即早产和胎龄)之间的关系。
采用多元线性和逻辑回归技术,对 920 名黑人和/或拉丁裔青少年和年轻女性的样本中,妊娠特异性应激(在第二和第三孕期测量)与妊娠时间(即早产和胎龄)之间的关系进行了检验。
第二孕期妊娠特异性应激与早产或胎龄无关。第三孕期妊娠特异性应激与早产有关,但与胎龄无关。第二至第三孕期妊娠特异性应激的变化与早产的可能性增加和胎龄缩短显著相关,即使在控制了重要的生物学、行为、心理、人际和社会文化风险因素后也是如此。
这些发现强调了在整个孕期测量妊娠特异性应激的重要性,因为从第二孕期到第三孕期的纵向变化与早产的胎龄(即二分变量(早产)和连续变量(胎龄))显著相关。此外,这是第一项在这个研究不足的人群中观察到妊娠特异性应激与胎龄关系的研究,该人群在年龄、种族和民族方面具有独特性。