Graduate School of Human Sciences, Osaka, Japan.
Psychiatry Clin Neurosci. 2014 Jul;68(7):534-41. doi: 10.1111/pcn.12165. Epub 2014 Mar 17.
Patients with schizophrenia have been reported to perform worse than non-schizophrenic populations on neuropsychological tests, which may be affected by cultural factors. The aim of this study was to examine the performance of a sizable number of patients with schizophrenia on the Japanese version of the Wechsler Adult Intelligence Scale-III (WAIS-III) compared with healthy controls.
Performance on the WAIS-III was evaluated in 157 Japanese patients with schizophrenia and in 264 healthy control subjects.
All IQ scores and four indices from the WAIS-III were impaired for patients with schizophrenia compared with healthy controls. Processing Speed was markedly disturbed, approximately 2 SD below that of the healthy control group. Among the 13 subtests, Comprehension (z = -1.70, d = 1.55), Digit Symbol Coding (z = -1.84, d = 1.88), and Symbol Search (z = -1.85, d = 1.77) were profoundly impaired relative to the healthy controls.
These results indicate that the pattern and degree of impairment, as evaluated by the WAIS-III, in Japanese patients are similar to those previously reported in English-speaking patients and that the deficits of some neuropsychological domains relevant to functional outcomes are universally characteristic of schizophrenia.
据报道，精神分裂症患者在神经心理学测试中的表现不如非精神分裂症患者，这可能受到文化因素的影响。本研究的目的是检查大量日本精神分裂症患者在韦氏成人智力量表第三版（WAIS-III）上的表现与健康对照组相比的情况。
评估了 157 名日本精神分裂症患者和 264 名健康对照组在 WAIS-III 上的表现。
与健康对照组相比，所有精神分裂症患者的智商得分和 WAIS-III 的四个指数均受损。处理速度明显受到干扰，大约比健康对照组低 2 个标准差。在 13 个分测验中，理解（z=-1.70，d=1.55）、数字符号编码（z=-1.84，d=1.88）和符号搜索（z=-1.85，d=1.77）明显受损。
这些结果表明，WAIS-III 评估的日本患者的损伤模式和程度与以前在英语患者中报告的相似，并且与功能结果相关的一些神经心理学领域的缺陷普遍是精神分裂症的特征。
