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颈动脉内膜切除术术后延长住院时间的当代预测因素。

Contemporary predictors of extended postoperative hospital length of stay after carotid endarterectomy.

机构信息

Northwestern Memorial Hospital, Chicago, Ill.

Division of Vascular and Endovascular Surgery, Brigham and Woman's Hospital, Boston, Mass.

出版信息

J Vasc Surg. 2014 May;59(5):1282-90. doi: 10.1016/j.jvs.2013.11.090. Epub 2014 Jan 18.

DOI:10.1016/j.jvs.2013.11.090
PMID:24447544
Abstract

INTRODUCTION

Hospital length of stay (LOS) contributes to costs. Carotid endarterectomy (CEA) is performed frequently by vascular surgeons, making contemporary CEA LOS rates and predictors vital knowledge for quality evaluation and cost containment initiatives.

METHODS

Using a prospective single-institution database, we retrospectively identified consecutive patients undergoing CEA from 2001 to 2011. Demographic and perioperative factors were prospectively collected. The primary end point was extended postoperative LOS (ELOS), defined as postoperative LOS ≥2 days. Factors associated with ELOS were analyzed in a multivariable logistic regression model. Rates of 1-year readmission and death were compared with the Kaplan-Meier method (log-rank test).

RESULTS

Eight hundred forty patients underwent 897 CEAs with 39% of procedures among females and 35% for symptomatic disease. One hundred two (11.4%) patients were inpatients prior to the day of CEA ("preadmitted"); their preoperative days by definition are not included in ELOS. Median postoperative LOS was 1 day (interquartile range, 1-2). Four hundred fourteen patients (46.2%) had ELOS. Preadmission was associated with ELOS (72% vs 41%; P < .01) and ELOS patients were less likely to be discharged home (11.9% vs 1.5%; P < .01). There was no association between ELOS and unplanned 30-day postdischarge readmission (6.0% vs 7.0%; P = .59). On multivariable analysis, preoperative factors significantly associated with ELOS included preadmission (adjusted odds ratio [OR], 3.3; 95% confidence interval [CI], 1.9-5.7; P < .001), history of congestive heart failure (OR, 2.1; 95% CI, 1.1-4.2; P = .03), female gender (OR, 1.9; 95% CI, 1.4-2.6; P < .001), and history of chronic obstructive pulmonary disease (OR, 1.7; 95% CI, 1.0-2.9; P = .04). Operative factors included electroencephalography change (OR, 1.9; 95% CI, 1.2-3.2; P = .01), operating room start time after 12:00 pm (OR, 1.7; 95% CI, 1.2-2.4; P < .01), and total operating room time (OR, 1.5 per hour; 95% CI, 1.2-2.9; P < .01). Postoperative factors included transfer to intensive care unit (OR, 5.4; 95% CI, 3.1-9.4; P < .01), number of in-hospital postoperative complications (OR, 3.7; 95% CI, 2.2-6.5; P < .01), and Foley catheter placement (OR, 2.1; 95% CI, 1.3-3.4; P < .01). Over 1 year, ELOS was associated with increased hospital readmission (93.6% vs 84.7%; log-rank test, P < .01) and decreased survival (95.1% vs 98.3%; log-rank test, P < .01).

CONCLUSIONS

Nearly half of CEA patients were discharged on or after postoperative day 2. Interventions on modifiable risk factors, such as early Foley catheter placement to prevent urinary retention and morning CEA scheduling, may decrease LOS. ELOS may identify a subset of patients at increased risk for long-term readmission and mortality.

摘要

简介

住院时间(LOS)是医疗费用的一个重要影响因素。颈动脉内膜切除术(CEA)经常由血管外科医生进行,因此了解当代 CEA LOS 率和预测因素对于质量评估和成本控制措施至关重要。

方法

我们使用前瞻性单中心数据库,回顾性地确定了 2001 年至 2011 年间接受 CEA 的连续患者。前瞻性收集了人口统计学和围手术期因素。主要终点是延长术后 LOS(ELOS),定义为术后 LOS≥2 天。使用多变量逻辑回归模型分析与 ELOS 相关的因素。Kaplan-Meier 方法(对数秩检验)比较了 1 年再入院率和死亡率。

结果

840 例患者进行了 897 次 CEA,其中 39%为女性,35%为症状性疾病。102 例(11.4%)患者在 CEA 前一天已住院(“预住院”);根据定义,他们的术前天数不计入 ELOS。中位术后 LOS 为 1 天(四分位距,1-2)。414 例(46.2%)患者出现 ELOS。预住院与 ELOS 相关(72% vs 41%;P<0.01),ELOS 患者更不可能出院回家(11.9% vs 1.5%;P<0.01)。ELOS 与 30 天计划外出院后再入院之间无关联(6.0% vs 7.0%;P=0.59)。多变量分析显示,术前因素与 ELOS 显著相关,包括预住院(调整后的优势比[OR],3.3;95%置信区间[CI],1.9-5.7;P<0.001)、充血性心力衰竭史(OR,2.1;95%CI,1.1-4.2;P=0.03)、女性(OR,1.9;95%CI,1.4-2.6;P<0.001)和慢性阻塞性肺疾病史(OR,1.7;95%CI,1.0-2.9;P=0.04)。手术因素包括脑电图变化(OR,1.9;95%CI,1.2-3.2;P=0.01)、手术室开始时间在下午 12:00 点后(OR,1.7;95%CI,1.2-2.4;P<0.01)和总手术室时间(OR,每小时增加 1.5 小时;95%CI,1.2-2.9;P<0.01)。术后因素包括转至重症监护病房(OR,5.4;95%CI,3.1-9.4;P<0.01)、术后院内并发症数量(OR,3.7;95%CI,2.2-6.5;P<0.01)和 Foley 导管放置(OR,2.1;95%CI,1.3-3.4;P<0.01)。在 1 年内,ELOS 与更高的医院再入院率(93.6% vs 84.7%;对数秩检验,P<0.01)和降低的生存率(95.1% vs 98.3%;对数秩检验,P<0.01)相关。

结论

近一半的 CEA 患者在术后第 2 天或第 2 天出院。干预可改变的风险因素,如预防尿潴留的早期 Foley 导管放置和早上安排 CEA,可能会降低 LOS。ELOS 可能会识别出一组长期再入院和死亡率较高的患者。

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