Saha Sibu P, Saha Subhajit, Vyas Krishna S
Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky.
MediCiti Institute of Medical Science, Hyderabad, India.
Int J Angiol. 2015 Sep;24(3):223-35. doi: 10.1055/s-0035-1558645. Epub 2015 Aug 14.
Background Stroke is the number one cause of disability and third leading cause of death among adults in the United States. A major cause of stroke is carotid artery stenosis (CAS) caused by atherosclerotic plaques. Randomized trials have varying results regarding the equivalence and perioperative complication rates of stents versus carotid endarterectomy (CEA) in the management of CAS. Objectives We review the evidence for the current management of CAS and describe the current concepts and practice patterns of CEA. Methods A literature search was conducted using PubMed to identify relevant studies regarding CEA and stenting for the management of CAS. Results The introduction of CAS has led to a decrease in the percentage of CEA and an increase in the number of CAS procedures performed in the context of all revascularization procedures. However, the efficacy of stents in patients with symptomatic CAS remains unclear because of varying results among randomized trials, but the perioperative complication rates exceed those found after CEA. Conclusions Vascular surgeons are uniquely positioned to treat carotid artery disease through medical therapy, CEA, and stenting. Although data from randomized trials differ, it is important for surgeons to make clinical decisions based on the patient. We believe that CAS can be adopted with low complication rate in a selected subgroup of patients, but CEA should remain the standard of care. This current evidence should be incorporated into practice of the modern vascular surgeon.
在美国成年人中,中风是导致残疾的首要原因,也是第三大死因。中风的一个主要原因是动脉粥样硬化斑块导致的颈动脉狭窄(CAS)。在CAS的治疗中,关于支架与颈动脉内膜切除术(CEA)的等效性和围手术期并发症发生率,随机试验有不同的结果。
我们回顾了当前CAS治疗的证据,并描述了CEA的当前概念和实践模式。
使用PubMed进行文献检索,以确定关于CEA和支架置入术治疗CAS的相关研究。
CAS的引入导致CEA的比例下降,并且在所有血管重建手术中,CAS手术的数量增加。然而,由于随机试验结果不同,有症状的CAS患者中支架的疗效仍不明确,但围手术期并发症发生率超过CEA术后的发生率。
血管外科医生在通过药物治疗、CEA和支架置入术治疗颈动脉疾病方面具有独特的地位。尽管随机试验的数据不同,但外科医生根据患者情况做出临床决策很重要。我们认为,在选定的患者亚组中可以采用CAS,且并发症发生率较低,但CEA仍应是治疗的标准。当前的这些证据应纳入现代血管外科医生的实践中。