Ding Minli, Song Xueqin, Zhao Jingyuan, Gao Jinsong, Li Xue, Yang Ge, Wang Xiujuan, Harrington Amy, Fan Xiaoduo, Lv Luxian
Henan Province Biological Psychiatry Key Laboratory, Xinxiang Medical University, Xinxiang, China; Henan Province Mental Hospital, The Second Affiliated Hospital/Xinxiang Medical University, Xinxiang, China.
The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China; Psychotic Disorders Program, UMass Memorial Medical Center/University of Massachusetts Medical School, Worcester, MA, United States.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:78-82. doi: 10.1016/j.pnpbp.2014.01.001. Epub 2014 Jan 19.
The present study was to examine the role of pro-inflammatory T helper 17 (Th17) cells in drug naïve, first episode schizophrenia.
Patients with normal weight, drug naïve, first episode schizophrenia and healthy controls were enrolled in the study. Flow cytometric analysis was performed to analyze the proportion of Th17 cells among the CD4(+) T cells. Plasma levels of interleukin-17 (IL-17), interferon-γ (IFN-γ) and interleukin-6 (IL-6) were examined using enzyme-linked immunosorbent assay (ELISA). Psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). All measures were repeated for the patient group after 4 weeks of risperidone treatment.
Sixty-nine patients with normal weight, drug naïve, first episode schizophrenia and 60 healthy controls were enrolled. At baseline, the patient group hadz significantly higher proportions of Th17 cells and plasma levels of IFN-γ and IL-6 compared with the control group (p's<0.01). Within the patient group, there were significant positive relationships between the proportion of Th17 cells, plasma levels of IL-17, IFN-γ, IL-6 and the PANSS total score after controlling for potential confounding variables (p's<0.05). After 4weeks of risperidone treatment, the proportion of Th17 cells decreased significantly (p <0.001), and there was a significant positive relationship between the PANSS total score change rate and the change in proportion of Th17 cells (p = 0.039).
Patients with normal weight, drug naïve, first episode schizophrenia present activation of Th17 cells, which might be associated with therapeutic response after risperidone treatment.
本研究旨在探讨促炎性辅助性T细胞17（Th17）在未用药的首发精神分裂症中的作用。
纳入体重正常、未用药的首发精神分裂症患者及健康对照者进行研究。采用流式细胞术分析CD4(+)T细胞中Th17细胞的比例。采用酶联免疫吸附测定（ELISA）检测血浆白细胞介素-17（IL-17）、干扰素-γ（IFN-γ）和白细胞介素-6（IL-6）水平。使用阳性和阴性症状量表（PANSS）评估精神病理学。对患者组在利培酮治疗4周后重复所有测量。
纳入69例体重正常、未用药的首发精神分裂症患者和60例健康对照者。在基线时，与对照组相比，患者组Th17细胞比例以及IFN-γ和IL-6血浆水平显著更高（p值<0.01）。在患者组内，在控制潜在混杂变量后，Th17细胞比例、IL-17、IFN-γ、IL-6血浆水平与PANSS总分之间存在显著正相关（p值<0.05）。利培酮治疗4周后，Th17细胞比例显著下降（p<0.001），且PANSS总分变化率与Th17细胞比例变化之间存在显著正相关（p = 0.039）。
体重正常、未用药的首发精神分裂症患者存在Th17细胞激活，这可能与利培酮治疗后的治疗反应相关。
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