The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China; Henan Province Biological Psychiatry Key Laboratory, Xinxiang Medical University, Xinxiang, China; Psychotic Disorders Program, UMass Memorial Medical Center/University of Massachusetts Medical School, Worcester, MA, United States.
Schizophr Res. 2013 Oct;150(1):269-73. doi: 10.1016/j.schres.2013.07.044. Epub 2013 Aug 19.
The study was to examine the levels of adiponectin (APN) and other cytokines, and body metabolism in drug naïve, first episode schizophrenia patients with normal weight.
Ninety-six drug naïve, first episode schizophrenia patients with normal weight (SZ group), 60 healthy individuals with normal weight (control group), and 60 overweight or obese but otherwise healthy individuals (obesity group) were enrolled in the study. Serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and APN were measured using enzyme linked immunosorbent assay (ELISA). Glucose oxidase was used to measure plasma glucose level. Lipid levels were measured using the enzymatic colorimetric method.
Serum levels of IL-1β, IL-6 and TNF-α in both the SZ group and the obesity group were significantly higher than those in the control group (p's<0.001). There were no significant differences between the SZ group and the obesity group on those cytokines (p's>0.05). In addition, the levels of APN were significantly higher in the SZ group (p<0.001), and significantly lower in the obesity group (p<0.01) compared with the control group. Further, there were significant positive relationships between levels of APN and levels of other cytokines within the SZ group (p's<0.05); in contrast, there were significant negative relationships between levels of APN and levels of other cytokines within the obesity group (p's<0.05). Fasting serum levels of glucose, LDL, triglycerides and total cholesterol were significantly higher, and fasting serum levels of HDL were significantly lower in the obesity group compared with the other two groups (p's<0.01). There were no significant differences in any of the metabolic parameters between the control group and the SZ group (p's>0.05).
Drug naïve, first episode schizophrenia patients with normal weight seem to present an up-regulated inflammatory status as reflected by elevated levels of IL-1β, IL-6, and TNF-α. APN may play a unique pro-inflammatory role in this patient population. Implications of the findings in relation to the pathogenesis of schizophrenia and the vulnerability for metabolic problems were discussed.
本研究旨在探讨瘦体质首发精神分裂症患者脂联素（APN）和其他细胞因子水平与机体代谢的关系。
选取 96 例瘦体质首发精神分裂症患者（SZ 组）、60 例健康瘦体质者（对照组）和 60 例超重或肥胖但健康者（肥胖组）。采用酶联免疫吸附法（ELISA）检测血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和 APN 水平。葡萄糖氧化酶法检测血浆葡萄糖水平。酶比色法检测血脂水平。
SZ 组和肥胖组患者血清 IL-1β、IL-6 和 TNF-α水平均明显高于对照组（p 值均<0.001），两组间上述细胞因子差异无统计学意义（p 值均>0.05）。SZ 组患者 APN 水平明显高于对照组（p 值<0.001），肥胖组患者 APN 水平明显低于对照组（p 值<0.01）。此外，SZ 组患者 APN 水平与其他细胞因子水平呈显著正相关（p 值均<0.05），肥胖组患者 APN 水平与其他细胞因子水平呈显著负相关（p 值均<0.05）。肥胖组患者空腹血糖、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）和总胆固醇（TC）水平明显高于其他两组（p 值均<0.01），高密度脂蛋白胆固醇（HDL-C）水平明显低于其他两组（p 值均<0.01）。对照组和 SZ 组患者的各项代谢指标差异均无统计学意义（p 值均>0.05）。
瘦体质首发精神分裂症患者似乎存在炎症状态上调，表现为 IL-1β、IL-6 和 TNF-α水平升高。APN 可能在该患者群体中发挥独特的促炎作用。文中还讨论了这些发现与精神分裂症发病机制和代谢问题易感性的关系。
