DBU 活化的 N-卤代脒促进的炔基氨卤化反应：卤代烯胺的直接合成。
Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines.
机构信息
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
出版信息
Chem Commun (Camb). 2014 Mar 4;50(18):2360-3. doi: 10.1039/c3cc49572h. Epub 2014 Jan 22.
PMID:24448462
Abstract
Activated by DBU, N-haloimides can be used as both halogen and nitrogen sources to achieve the difunctionalization of terminal alkynes, giving rise to useful halogenated enamines with high efficiency and high regio- and stereoselectivities. The cascade reaction features simple manipulation, mild conditions, a broad substrate scope, readily available reagents, and atom-economy.
摘要
在 DBU 的激活作用下，N-卤代酰亚胺既可用作卤素源，也可用作氮源，从而高效高区域和立体选择性地实现末端炔烃的双官能化，得到有用的卤化烯胺。该级联反应具有操作简单、条件温和、底物范围广、试剂易得和原子经济性等特点。
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