Moreno Natália Cestari, Sofia Silvia Helena, Martinez Claudia B R
Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, PB 6001, 86051-990 Londrina, PR, Brazil.
Departamento de Biologia Geral, Universidade Estadual de Londrina, PB 6001, 86051-990 Londrina, PR, Brazil.
Environ Toxicol Pharmacol. 2014 Jan;37(1):448-54. doi: 10.1016/j.etap.2013.12.012. Epub 2013 Dec 31.
Roundup Transorb (RT) is a glyphosate-based herbicide and despite its wide use around the world there are few studies comparing the effects of the active ingredient with the formulated product. In this context the purpose of this study was to compare the genotoxicity of the active ingredient glyphosate with the formulated product RT in order to clarify whether the active ingredient and the surfactant of the RT formula may exert toxic effects on the DNA molecule in juveniles of fish Prochilodus lineatus. Erythrocytes and gill cells of fish exposed to glyphosate and to RT showed DNA damage scores significantly higher than control animals. These results revealed that both glyphosate itself and RT were genotoxic to gill cells and erythrocytes of P. lineatus, suggesting that their use should be carefully monitored considering their potential impact on tropical aquatic biota.
农达转霸（RT）是一种基于草甘膦的除草剂，尽管它在全球广泛使用，但很少有研究比较其活性成分与制剂产品的效果。在此背景下，本研究的目的是比较活性成分草甘膦与制剂产品RT的遗传毒性，以阐明RT配方中的活性成分和表面活性剂是否可能对细纹锯脂鲤幼鱼的DNA分子产生毒性作用。暴露于草甘膦和RT的鱼的红细胞和鳃细胞显示出的DNA损伤评分显著高于对照动物。这些结果表明，草甘膦本身和RT对细纹锯脂鲤的鳃细胞和红细胞均具有遗传毒性，这表明考虑到它们对热带水生生物群的潜在影响，应谨慎监测它们的使用。
