Isik-Balci Yasemin, Tancer-Elci Hazal, Bor-Kucukatay Melek, Kilic-Erkek Ozgen, Kilic-Toprak Emine, Senol Hande, Rota Simin
Faculty of Medicine, Department of Pediatric Hematology, Pamukkale University, Kinikli, Denizli, Turkey.
Faculty of Medicine, Department of Pediatrics, Pamukkale University, Kinikli, Denizli, Turkey.
Clin Hemorheol Microcirc. 2015 Jul 16;60(2):179-89. doi: 10.3233/CH-141811.
We aimed to investigate the effects of iron deficiency anemia (IDA) and vitamin B12 deficiency coexisting with IDA which is called as mixed anemia (MA) on hemorheological parameters, to compare them with each other and healthy controls, and to assess the changes in hemorheological parameters after treatment.
32 IDA patients (mean age:6.3 ± 5.3 years), 30 MA patients (mean age:7.2 ± 5.4 years), and 31 healthy controls (mean age:7.1 ± 5.2 years) were enrolled. Erythrocyte deformability and aggregation were determined by an ectacytometer, plasma and whole blood viscosities by a cone-plate rotational viscometer. Differences between IDA and MA, and healthy controls were compared. Hemorheological parameters were repeated in the patient groups after treatment and compared with the initial results.
In both of the patient groups, erythrocyte deformability, whole blood and plasma viscosities were found to be significantly decreased before treatment, compared with the controls. After treatment these parameters were found to be increased significantly. There were no significant differences in these parameters between the IDA and MA group. Additionally, no statistically significant alteration was found in erythrocyte aggregation measurements of both patient groups.
This study indicates that IDA and MA have similar effects on hemorheological parameters. When vitamin B12 deficiency accompanies IDA which is called as MA, no further alterations occur in hemorheological parameters. The adequate treatment of these anemias not only corrects the hematological parameters, but also by helping to normalize the hemorheological parameters, may contribute to the regulation of microvascular perfusion.
我们旨在研究缺铁性贫血（IDA）以及与IDA并存的维生素B12缺乏即混合性贫血（MA）对血液流变学参数的影响，将它们相互之间以及与健康对照进行比较，并评估治疗后血液流变学参数的变化。
纳入32例IDA患者（平均年龄：6.3±5.3岁）、30例MA患者（平均年龄：7.2±5.4岁）和31例健康对照（平均年龄：7.1±5.2岁）。通过体外细胞仪测定红细胞变形性和聚集性，通过锥板旋转粘度计测定血浆和全血粘度。比较IDA组和MA组与健康对照之间的差异。治疗后对患者组重复检测血液流变学参数并与初始结果进行比较。
与对照组相比，两个患者组在治疗前红细胞变形性、全血和血浆粘度均显著降低。治疗后这些参数显著升高。IDA组和MA组在这些参数上无显著差异。此外，两个患者组的红细胞聚集性测量均未发现有统计学意义的改变。
本研究表明IDA和MA对血液流变学参数有相似影响。当维生素B12缺乏伴随IDA即MA时，血液流变学参数无进一步改变。对这些贫血的适当治疗不仅能纠正血液学参数，还可能通过帮助使血液流变学参数正常化，有助于调节微血管灌注。
