侵袭性淋巴瘤传统化疗的失败
Failure of conventional chemotherapy in aggressive lymphomas.
作者信息
Cunningham D, Hepplestone A, Gilchrist N L, Dagg J H, Evans I L, Soukop M
机构信息
Department of Medical Oncology, Royal Infirmary, UK.
出版信息
Postgrad Med J. 1987 Jan;63(735):11-5. doi: 10.1136/pgmj.63.735.11.
Between 1975 and 1982 in 2 centres in Glasgow, 53 previously untreated patients with aggressive non-Hodgkin's lymphomas received chemotherapy consisting of one of the following regimens-CVP, MOPP, CHOP or BACOP. Twenty nine patients (55%) entered complete remission (CR), 20 (38%) had partial remission (PR) and 4 (7%) had progressive disease (PD). Of the 29 patients in CR, 9 have relapsed and died, 5 died of infection, 4 died of non-malignant causes, and 11 (21%) remain alive and disease free. The median survival for the CR group is 40 months. All of the patients in the PR and PD group are dead, median survival 11 months. These chemotherapy regimens will cure only the minority of patients with aggressive lymphomas and the use of more intensive regimens is indicated.
1975年至1982年间，在格拉斯哥的2个中心，53例先前未接受治疗的侵袭性非霍奇金淋巴瘤患者接受了以下化疗方案之一——CVP、MOPP、CHOP或BACOP。29例患者（55%）进入完全缓解（CR），20例（38%）部分缓解（PR），4例（7%）疾病进展（PD）。在29例CR患者中，9例复发并死亡，5例死于感染，4例死于非恶性原因，11例（21%）仍存活且无疾病。CR组的中位生存期为40个月。PR组和PD组的所有患者均死亡，中位生存期为11个月。这些化疗方案仅能治愈少数侵袭性淋巴瘤患者，因此需要使用更强效的方案。
Zotero 插件