Ertem Ahmet Göktuğ, Erayman Ali, Efe Tolga Han, Duran Karaduman Bilge, Aydın Halil Ibrahim, Bilge Mehmet
Clinic of Cardiology, Ankara Penal Instution Campus State Hospital; Ankara-Turkey.
Anadolu Kardiyol Derg. 2014 Mar;14(2):115-20. doi: 10.5152/akd.2014.4742. Epub 2014 Jan 14.
This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness.
Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation between epicardial fat tissue thickness, which was measured by echocardiography and serum paraoxonase 1 level. Also correlation analysis was performed to show correlation between patients' clinical and laboratory findings and the level of serum paraoxonase 1 (PON 1) and the epicardial fat tissue thickness. Pearson and Spearman test were used for correlation analysis.
No linear correlation between epicardial fat tissue thickness and serum PON 1 found (correlation coefficient: -0.127, p=0.069). When epicardial fat tissue thickness were grouped as 7 mm and over, and below, and 5 mm and over, and below, serum PON 1 level were significantly lower in ≥7 mm group (PON1 : 168.9 U/L) than <7 mm group (PON 1: 253.9 U/L) (p<0.001). Also hypertension prevalence was increased in ≥7 mm group (p=0.001). Serum triglyceride was found to be higher in ≥7 mm group (p=0.014), body mass index was found higher in ≥5 mm group (p=0.006).
Serum PON 1 level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness.
本研究旨在揭示血清对氧磷酶1水平与心外膜脂肪组织厚度之间的关系。
本横断面观察性研究纳入了270例无任何动脉粥样硬化疾病史的患者。通过超声心动图测量心外膜脂肪组织厚度，并与血清对氧磷酶1水平进行相关性分析。同时，对患者的临床和实验室检查结果与血清对氧磷酶1（PON 1）水平及心外膜脂肪组织厚度进行相关性分析。采用Pearson和Spearman检验进行相关性分析。
未发现心外膜脂肪组织厚度与血清PON 1之间存在线性相关性（相关系数：-0.127，p = 0.069）。当将心外膜脂肪组织厚度分为7mm及以上和以下，以及5mm及以上和以下时，≥7mm组的血清PON 1水平（PON1：168.9 U/L）显著低于<7mm组（PON 1：253.9 U/L）（p<0.001）。此外，≥7mm组的高血压患病率升高（p = 0.001）。≥7mm组的血清甘油三酯水平较高（p = 0.014），≥5mm组的体重指数较高（p = 0.006）。
血清PON 1水平与心外膜脂肪组织厚度无关。但心外膜脂肪组织厚度≥7mm的患者PON 1水平较低。因此，在心外膜脂肪组织厚度≥7mm的患者中可发现动脉粥样硬化进展加快。
