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孤立性代谢综合征患者的心外膜脂肪组织厚度与氧化应激参数之间的关联：一种多标志物方法

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach.

作者信息

Demir Bulent, Demir Esra, Acıksarı Gonul, Uygun Turgut, Utku Irem Kırac, Gedikbasi Asuman, Caglar Ilker Murat, Pirhan Osman, Tureli Hande Oktay, Oflar Ersan, Ungan İsmail, Ciftci Serkan, Karakaya Osman

机构信息

Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey.

Department of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey.

出版信息

Int J Endocrinol. 2014;2014:954045. doi: 10.1155/2014/954045. Epub 2014 Nov 2.

DOI:10.1155/2014/954045
PMID:25530760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4233660/
Abstract

The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 ± 2.0 mm and 4.0 ± 1.0 mm, resp.; P < 0.001). The level of TOS was higher in the MeS group compared to the control group (P < 0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P < 0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P < 0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.

摘要

代谢综合征（MeS）患者群体中，心血管疾病和2型糖尿病的风险显著增加。本研究旨在调查MeS患者的心外膜脂肪组织厚度（EATT）与氧化应激参数之间的关联。该研究纳入了181名患者，其中包括连续92名患有MeS的患者作为患者组，以及连续89名年龄和性别相似的患者作为对照组。通过经胸超声心动图评估EATT。测量血清总氧化状态（TOS）、总抗氧化能力（TAS）、对氧磷酶-1（PON-1）和芳基酯酶活性水平。与对照组相比，MeS组的EATT更高（分别为6.0±2.0毫米和4.0±1.0毫米；P<0.001）。与对照组相比，MeS组的TOS水平更高（P<0.001）。此外，与对照组相比，MeS组的TAS水平更高（P<0.001）。此外，与对照组相比，MeS组的血清PON-1和芳基酯酶水平更低（P<0.001）。EAT可能通过导致MeS患者氧化应激增加而增加心血管疾病风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/f968539ef465/IJE2014-954045.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/89c765bacbb0/IJE2014-954045.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/20a45d6d6865/IJE2014-954045.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/3923ee60a3b4/IJE2014-954045.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/f968539ef465/IJE2014-954045.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/89c765bacbb0/IJE2014-954045.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/20a45d6d6865/IJE2014-954045.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/3923ee60a3b4/IJE2014-954045.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8faf/4233660/f968539ef465/IJE2014-954045.004.jpg

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