十二指肠内注入酸和高渗溶液可抑制大鼠胃中五肽胃泌素刺激的胃酸分泌，但不影响组胺的释放。

Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not histamine mobilization in the rat stomach.

作者信息

Emås S, Håkanson R

机构信息

Dept. of Surgery, Karolinska Hospital, Stockholm, Sweden.

出版信息

Scand J Gastroenterol. 1987 Sep;22(7):776-80. doi: 10.3109/00365528708991913.

DOI:10.3109/00365528708991913

PMID:2445017

Abstract

In chronic gastric fistula rats provided with a duodenal loop anastomosed to the jejunum (Roux-en-Y), maximal stimulation of acid secretion by continuous intravenous infusion of pentagastrin produced a 15-fold increase of gastric histidine decarboxylase activity. Intraduodenal instillation of 0.20 M HCl or 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) inhibited the maximal acid response to pentagastrin by 61% and hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl by 79% but did not suppress the pentagastrin-induced increase in enzyme activity. Hence, instillation of HCl and/or hyperosmolal PEG solution in the duodenum depresses the responsiveness of the parietal cells to pentagastrin without interfering with pentagastrin-induced activation of gastric histamine formation.

摘要

在患有慢性胃瘘且十二指肠袢与空肠吻合（Roux-en-Y）的大鼠中，通过持续静脉输注五肽胃泌素对胃酸分泌进行最大刺激时，胃组织中组氨酸脱羧酶活性增加了15倍。十二指肠内滴注0.20 M盐酸或1200 mOsm·kg⁻¹的聚乙二醇（PEG）溶液，可使对五肽胃泌素的最大酸反应分别抑制61%和79%（高渗PEG溶液，1200 mOsm·kg⁻¹的0.20 M盐酸），但不抑制五肽胃泌素诱导的酶活性增加。因此，十二指肠内滴注盐酸和/或高渗PEG溶液可降低壁细胞对五肽胃泌素的反应性，而不干扰五肽胃泌素诱导的胃组胺形成激活。