慢性胃瘘大鼠上段小肠中的酸性和高渗溶液通过不同机制抑制胃酸分泌。

Acid and hyperosmolal solutions in the upper intestine of chronic gastric fistula rats inhibit gastric acid secretion by different mechanisms.

作者信息

Wallin C, Emås S, Nylander G

出版信息

Scand J Gastroenterol. 1985 Nov;20(9):1083-90. doi: 10.3109/00365528509088876.

Abstract

In chronic gastric fistula rats 0.20 M HCl and 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) infused into a duodenal loop anastomosed to the jejunum (Roux-en-Y) produced maximal inhibition of pentagastrin-stimulated acid secretion, which amounted to 60% and 50%, respectively. In the present study in Roux-en-Y rats with gastric fistula, perfusion of the loop with hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl produced a greater reduction of the maximal response to pentagastrin (91% inhibition) than perfusion with 0.20 M HCl (64%), suggesting that HCl and hyperosmolal solution inhibit secretion by different mechanisms. The maximal acid response to histamine was more resistant to inhibition than that to pentagastrin; 0.20 M HCl inhibited secretion by 43%, 1200 mOsm X kg-1 of PEG solution by 42%, and hyperosmolal 0.20 M HCl by 60%. The results suggest that HCl and hyperosmolal solution also inhibit histamine-stimulated secretion by different mechanisms. The anatomical sites of the mechanisms remain to be established.

摘要

在慢性胃瘘大鼠中，将0.20 M盐酸和1200 mOsm·kg⁻¹的聚乙二醇（PEG）溶液注入与空肠吻合的十二指肠袢（Roux-en-Y），可最大程度抑制五肽胃泌素刺激的胃酸分泌，抑制率分别达60%和50%。在本研究中，对有胃瘘的Roux-en-Y大鼠，用高渗（1200 mOsm·kg⁻¹的PEG溶液）0.20 M盐酸灌注肠袢，与用0.20 M盐酸灌注相比，对五肽胃泌素最大反应的降低幅度更大（抑制率91%）（抑制率64%），这表明盐酸和高渗溶液通过不同机制抑制分泌。对组胺的最大酸反应比五肽胃泌素更具抗抑制性；0.20 M盐酸抑制分泌43%，1200 mOsm·kg⁻¹的PEG溶液抑制42%，高渗0.20 M盐酸抑制60%。结果表明，盐酸和高渗溶液也通过不同机制抑制组胺刺激的分泌。这些机制的解剖部位尚待确定。