在慢性胃瘘大鼠中，十二指肠酸灌注对五肽胃泌素刺激的胃酸分泌的抑制作用。

Inhibition of pentagastrin-stimulated gastric acid secretion by acid perfusion of the duodenum in chronic gastric fistula rats.

作者信息

Emås S, Nylander G, Wallin B, Wallin C

出版信息

Scand J Gastroenterol. 1983 Jul;18(5):685-90. doi: 10.3109/00365528309181658.

Abstract

The effect of duodenal acid perfusion on pentagastrin-stimulated gastric acid secretion was studied in Sprague-Dawley rats provided with a chronic gastric fistula, gastroenterostomy, and a 4-cm blind duodenal loop anastomosed to the jejunum. During maximal acid stimulation with intravenous pentagastrin (16 micrograms X kg-1 h-1) the loop was perfused with 0.15 M NaCl or 0.05 M, 0.10 M, or 0.20 M HCl at a rate of 2 ml X h-1. Perfusion with 0.05 M HCl did not significantly alter pentagastrin-stimulated secretion. 0.10 M and 0.20 M HCl reduced the 2-h acid response by 56% and 63%, respectively. Acid secretion returned to control level after cessation of acid perfusion. It is concluded that physiological amounts of HCl in the duodenum inhibits maximal acid secretion stimulated by pentagastrin in rats.

摘要

在具有慢性胃瘘、胃肠吻合术以及与空肠吻合的4厘米盲端十二指肠袢的斯普拉格-道利大鼠中，研究了十二指肠酸灌注对五肽胃泌素刺激胃酸分泌的影响。在用静脉注射五肽胃泌素（16微克×千克⁻¹×小时⁻¹）进行最大酸刺激期间，以2毫升×小时⁻¹的速率向肠袢灌注0.15M氯化钠或0.05M、0.10M或0.20M盐酸。用0.05M盐酸灌注并未显著改变五肽胃泌素刺激的分泌。0.10M和0.20M盐酸分别使2小时的酸反应降低了56%和63%。停止酸灌注后，胃酸分泌恢复到对照水平。得出的结论是，十二指肠中生理量的盐酸可抑制大鼠中五肽胃泌素刺激的最大胃酸分泌。