*Institut Curie, Centre de Recherche, F-75248 Paris, France.
†Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas/Universidad de Salamanca, 37007 Salamanca, Spain.
Biochem Soc Trans. 2014 Feb;42(1):201-5. doi: 10.1042/BST20130155.
Polarized cell growth requires a well-orchestrated number of events, namely selection of growth site, organization of cytoskeleton elements and delivery of new material to the growth region. The small Rho GTPase Cdc42 has emerged as a major organizer of polarized growth through its participation in many of these events. In the present short review, we focus on the regulation of Cdc42 activity and localization as well as how it controls downstream events necessary for polarized cell growth in Schizosaccharomyces pombe. Owing to the high level of similarity of the polarity pathways, analogies between fission yeast and other model systems can be useful to decipher how cells can actively define their shape by polarized growth.
极化细胞的生长需要一系列精心协调的事件，即生长部位的选择、细胞骨架元素的组织以及新物质向生长区域的输送。小 Rho GTPase Cdc42 通过参与其中许多事件，成为极化生长的主要组织者。在本综述中，我们重点介绍 Cdc42 活性和定位的调节，以及它如何控制裂殖酵母中极化细胞生长所需的下游事件。由于极性途径的高度相似性，裂殖酵母和其他模型系统之间的类比对于破译细胞如何通过极化生长积极定义其形状是有用的。
