日本兵库县临床分离的沙门氏菌菌株的抗菌药物耐药性（2009 - 2012年）
Antimicrobial resistance in Salmonella strains clinically isolated in Hyogo, Japan (2009-2012).
作者信息
Osawa Kayo, Shigemura Katsumi, Shimizu Rika, Kato Ayaka, Kimura Mayuha, Katayama Yuki, Okuya Yuma, Yutaka Shunichiro, Nishimoto Akiko, Kishi Akane, Fujiwara Miki, Yoshida Hiroyuki, Iijima Yoshio, Fujisawa Masato, Shirakawa Toshiro
机构信息
Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science.
出版信息
Jpn J Infect Dis. 2014;67(1):54-7. doi: 10.7883/yoken.67.54.
The purpose of this study was to examine the in vitro susceptibilities to antimicrobial agents and genetic diversity of 195 clinical strains of Salmonella spp., which were isolated and examined for the extended-spectrum β-lactamase (ESBL) blaCTX-M gene and the presence of gyrA, gyrB, parC, and parE genes mutations in Hyogo, Japan, from 2009 to 2012. Forty-three of the 195 strains were antimicrobial resistant. Two Salmonella enterica subsp. enterica strains, 1 serovar Schwarzengrund, and 1 serovar Enteritidis were identified as ESBL-producing strains possessing blaCTX-M-15 and blaCTX-M-2, respectively. Among 8 nalidixic acid-resistant strains, 7 had mutations in gyrA alone or in gyrA and parC. In conclusion, we identified CTX-M ESBL-producing Salmonella clinical strains with multidrug resistance. Further studies are needed to monitor these serious drug-resistant Salmonella strains in Japan.
本研究的目的是检测195株沙门氏菌临床菌株对抗菌药物的体外敏感性及其遗传多样性，这些菌株于2009年至2012年在日本兵库县分离得到，并检测了其超广谱β-内酰胺酶（ESBL）blaCTX-M基因以及gyrA、gyrB、parC和parE基因突变情况。195株菌株中有43株具有抗菌耐药性。鉴定出2株肠炎沙门氏菌亚种肠炎菌株、1株施瓦岑格伦德血清型菌株和1株肠炎血清型菌株分别为产生ESBL的菌株，分别携带blaCTX-M-15和blaCTX-M-2基因。在8株对萘啶酸耐药的菌株中，7株仅gyrA发生突变或gyrA和parC均发生突变。总之，我们鉴定出了产CTX-M ESBL的多重耐药沙门氏菌临床菌株。需要进一步研究以监测日本这些严重耐药的沙门氏菌菌株。
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