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分娩疼痛药物的使用与泌乳延迟之间的关系。

Relationship between use of labor pain medications and delayed onset of lactation.

作者信息

Lind Jennifer N, Perrine Cria G, Li Ruowei

机构信息

1Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

J Hum Lact. 2014 May;30(2):167-73. doi: 10.1177/0890334413520189. Epub 2014 Jan 22.

Abstract

BACKGROUND

Despite estimates that 83% of mothers in the United States receive labor pain medications, little research has been done on how use of these medications affect onset of lactation.

OBJECTIVE

To investigate whether use of labor pain medications is associated with delayed onset of lactation (DOL).

METHODS

We analyzed data from the 2005-2007 Infant Feeding Practices Study II, a longitudinal study of women from late pregnancy through the entire first year after birth (n = 2366). In multivariable logistic regression analyses, we assessed the relationship between mothers' use of labor pain medication/method and DOL (milk coming in > 3 days after delivery).

RESULTS

Overall, 23.4% of women in our sample experienced DOL. Compared with women who delivered vaginally and received no labor pain medication, women who received labor pain medications had a higher odds of experiencing DOL: vaginal with spinal/epidural only (aOR 2.05; 95% CI, 1.43-2.95), vaginal with spinal/epidural plus another medication (aOR 1.79; 95% CI, 1.16-2.76), vaginal with other labor pain medications only ([not spinal/epidural]; aOR 1.84; 95% CI, 1.14-2.98), planned cesarean section with spinal/epidural only (aOR 2.13; 95% CI, 1.39-3.27), planned cesarean with spinal/epidural plus another medication (aOR 2.67; 95% CI, 1.35-5.29), emergency cesarean with spinal/epidural only (aOR 2.17; 95% CI, 1.34-3.51), and emergency cesarean with spinal/epidural plus another medication (aOR 3.03; 95% CI, 1.77-5.18).

CONCLUSION

Mothers who received labor pain medications were more likely to report DOL, regardless of delivery method. This information could help inform clinical decisions regarding labor/delivery.

摘要

背景

尽管据估计美国83%的母亲在分娩时使用了镇痛药物,但关于这些药物的使用如何影响泌乳开始的研究却很少。

目的

调查分娩镇痛药物的使用是否与泌乳延迟开始(DOL)有关。

方法

我们分析了2005 - 2007年婴儿喂养实践研究II的数据,这是一项对从妊娠晚期到产后一整年的女性进行的纵向研究(n = 2366)。在多变量逻辑回归分析中,我们评估了母亲使用分娩镇痛药物/方法与泌乳延迟开始(产后3天以上才下奶)之间的关系。

结果

总体而言,我们样本中的23.4%的女性经历了泌乳延迟开始。与经阴道分娩且未使用分娩镇痛药物的女性相比,使用分娩镇痛药物的女性出现泌乳延迟开始的几率更高:仅使用脊髓/硬膜外麻醉的阴道分娩(调整后比值比[aOR] 2.05;95%置信区间[CI],1.43 - 2.95),使用脊髓/硬膜外麻醉加另一种药物的阴道分娩(aOR 1.79;95% CI,1.16 - 2.76),仅使用其他分娩镇痛药物(非脊髓/硬膜外麻醉)的阴道分娩(aOR 1.84;95% CI,1.14 - 2.98),仅使用脊髓/硬膜外麻醉的计划剖宫产(aOR 2.13;95% CI,1.39 - 3.27),使用脊髓/硬膜外麻醉加另一种药物的计划剖宫产(aOR 2.67;95% CI,1.35 - 5.29),仅使用脊髓/硬膜外麻醉的急诊剖宫产(aOR 2.17;95% CI,1.34 - 3.51),以及使用脊髓/硬膜外麻醉加另一种药物的急诊剖宫产(aOR 3.03;95% CI,1.77 - 5.18)。

结论

无论分娩方式如何,使用分娩镇痛药物的母亲更有可能报告泌乳延迟开始。这些信息有助于为有关分娩的临床决策提供参考。

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