Hansson C, Faergemann J, Swanbeck G
Department of Dermatology, Sahlgren's Hospital, Gothenburg, Sweden.
Acta Derm Venereol. 1987;67(4):341-5.
In 49 consecutive leg ulcer patients fungal cultures were taken from 4 different locations: the ulcer; the ulcer edge; 10 cm below the knee; and the toe-web. The patients had been treated with ACO Medicated Stockings in half of the cases, and the others were treated with several different bandages. Sera were analysed for antibodies against Candida albicans with the indirect immunofluorescence technique (IIF). The mean antibody titer was 434 in the patients with C. albicans in their ulcers, 123 in control patients with negative cultures in their ulcers and 258 in control patients with basalioma or actinic keratoses. Seven patients were culture positive for C. albicans, two patients had C. parapsilosis and one had growth of Trichophyton rubrum in their ulcers. Nine out of 10 patients with positive cultures had been treated with ACO Medicated Stockings (p less than 0.05). Covering a large area of the leg with an ointment impregnated stocking without preservatives seems to increase the risk for fungal infections.
对49例连续性腿部溃疡患者，从4个不同部位采集真菌培养样本：溃疡处、溃疡边缘、膝盖以下10厘米处以及趾间。一半患者接受了ACO药用弹力袜治疗，另一半患者则使用了几种不同的绷带进行治疗。采用间接免疫荧光技术（IIF）分析血清中抗白色念珠菌的抗体。溃疡处有白色念珠菌的患者平均抗体滴度为434，溃疡培养阴性的对照患者为123，患有基底细胞癌或光化性角化病的对照患者为258。7例患者溃疡处白色念珠菌培养呈阳性，2例患者溃疡处近平滑念珠菌培养呈阳性，1例患者溃疡处红色毛癣菌生长。培养阳性的10例患者中有9例接受了ACO药用弹力袜治疗（p<0.05）。用不含防腐剂的浸膏弹力袜覆盖腿部大面积区域似乎会增加真菌感染的风险。
