美国俄亥俄州斯图本维尔老年人队列中空气污染对血氧饱和度的短期影响。
Short-term effects of air pollution on oxygen saturation in a cohort of senior adults in Steubenville, Ohio.
机构信息
From the Departments of Environmental Health (Drs Luttmann-Gibson, Sarnat, Suh, Schwartz, Zanobetti, and Gold) and Biostatistics (Dr Coull), Harvard School of Public Health, Boston, Mass; Department of Environmental and Occupational Health (Dr Sarnat), Emory University, Atlanta, Ga; Department of Health Sciences (Dr Suh), Northeastern University, Boston, Mass; and Channing Laboratory (Drs Schwartz and Gold), Harvard Medical School, Boston, Mass.
出版信息
J Occup Environ Med. 2014 Feb;56(2):149-54. doi: 10.1097/JOM.0000000000000089.
OBJECTIVE
We examine whether ambient air pollution is associated with oxygen saturation in 32 elderly subjects in Steubenville, Ohio.
METHODS
We used linear mixed models to examine the effects of fine particulate matter less than 2.5 μm (PM(2.5)), sulfate (SO(4)(-2)), elemental carbon, and gases on median oxygen saturation.
RESULTS
An interquartile range increase of 13.4 μg/m in PM(2.5) on the previous day was associated with a decrease of -0.18% (95% confidence interval: -0.31 to -0.06) and a 5.1 μg/m(3) interquartile range increase in SO(4)(-2) on the previous day was associated with a decrease of -0.16% (95% confidence interval: -0.27 to -0.04) in oxygen saturation during the initial 5-minute rest period of the protocol.
CONCLUSIONS
Increased exposure to air pollution, including the nontraffic pollutant SO(4)(-2) from industrial sources, led to changes in oxygen saturation that may reflect particle-induced pulmonary inflammatory or vascular responses.
目的
我们在俄亥俄州斯图本维尔的 32 名老年受试者中研究环境空气污染与氧饱和度的关系。
方法
我们使用线性混合模型来研究细颗粒物小于 2.5 μm（PM（2.5））、硫酸盐（SO（4）（-2））、元素碳和气体对中值氧饱和度的影响。
结果
前一天 PM（2.5）增加 13.4μg/m，与氧饱和度下降 0.18%（95%置信区间：-0.31 至 -0.06）相关，前一天 SO（4）（-2）增加 5.1μg/m（3），与氧饱和度下降 0.16%（95%置信区间：-0.27 至 -0.04）相关，这是在协议的初始 5 分钟休息期内。
结论
接触更多的空气污染，包括来自工业源的非交通污染物 SO（4）（-2），导致氧饱和度发生变化，这可能反映出颗粒引起的肺部炎症或血管反应。
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