Clemens Benjamin, Voß Bianca, Pawliczek Christina, Mingoia Gianluca, Weyer David, Repple Jonathan, Eggermann Thomas, Zerres Klaus, Reetz Kathrin, Habel Ute
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School Interdisciplinary Center for Clinical Research, Medical School.
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School.
Cereb Cortex. 2015 Jul;25(7):1771-81. doi: 10.1093/cercor/bht366. Epub 2014 Jan 22.
Up to now, it remains unclear how monoamine oxidase A (MAOA), which has been repeatedly linked to aggression, affects brain activity within resting-state networks (RSN). Here, we used functional magnetic resonance imaging (fMRI) to test whether the MAOA genotype might influence activity within the common RSN. Our results demonstrate that during rest, participants with the low-activity genotype (MAOA-L) exhibit more activity within frontoparietal and temporal parts of the default mode network (DMN) and the cerebellum. The executive control and salience RSN revealed reduced activity for the MAOA-L group in several areas related to executive control, namely the right middle frontal gyrus (BA 6 and BA 9), and the dorsal part of the anterior cingulate cortex. Participants with the high-activity genotype (MAOA-H) showed increased activity in the posterior cingulate part of the DMN. Taken together, we found widespread hyperactivity within the DMN and reduced activity in brain areas related to executive and inhibitory control for the MAOA-L group. We discuss how these first results examining the influence of MAOA on the resting brain might be related to previous findings regarding the genetics of aggression, while acknowledging that this is an exploratory study which needs further confirmation.
到目前为止，一直不清楚与攻击行为反复相关的单胺氧化酶A（MAOA）如何影响静息态网络（RSN）内的大脑活动。在这里，我们使用功能磁共振成像（fMRI）来测试MAOA基因型是否可能影响常见RSN内的活动。我们的结果表明，在静息状态下，低活性基因型（MAOA-L）的参与者在默认模式网络（DMN）的额顶叶和颞叶部分以及小脑中表现出更多活动。执行控制和突显RSN显示，MAOA-L组在与执行控制相关的几个区域，即右侧额中回（BA 6和BA 9）以及前扣带回皮质的背侧部分，活动减少。高活性基因型（MAOA-H）的参与者在DMN的后扣带回部分表现出活动增加。综合来看，我们发现MAOA-L组的DMN内广泛存在活动亢进，而与执行和抑制控制相关的脑区活动减少。我们讨论了这些关于MAOA对静息大脑影响的初步结果可能如何与先前关于攻击行为遗传学的研究结果相关，同时承认这是一项需要进一步证实的探索性研究。
