Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA.
Neuropharmacology. 2019 Sep 15;156:107396. doi: 10.1016/j.neuropharm.2018.10.025. Epub 2018 Oct 23.
Disproportionate anger and reactive aggression in response to provocation are core symptoms of intermittent-explosive disorder (IED). Previous research shows a link between the propensity for aggression in healthy individuals and altered functioning of prefrontal-limbic and default-mode networks (DMN) at rest when no provocation is present. In a pilot study, we used resting-state functional magnetic resonance imaging to investigate the effects of pronounced reactive aggression in men, exemplified by IED, on the functional organization of resting-state brain networks including subcortical nodes such as the habenula previously implicated in aggression in preclinical models. Graph theory was applied to resting-state networks to determine alterations in global efficiency and clustering in high reactive aggressive men compared to low reactive aggressive men (controls). Further, we computed within-group correlations between trait aggression and graph measures, as well as within-group whole-brain seed-to-voxel regression analyses between trait aggression and habenula resting-state functional connectivity (rsFC). Reactive aggressive men compared to controls showed higher global efficiency in the left habenula, the left pulvinar in the thalamus, the left dorso-lateral prefrontal cortex, and the right temporal pole, as well as a trend for decreased clustering in DMN nodes. In the reactive aggressive group, high levels of trait aggression were linked to lower global efficiency of the left habenula, and to lower rsFC between the left habenula and the left ventro-lateral prefrontal cortex, a core region involved in inhibitory control. Together with preclinical evidence, our findings in men underline the relevance of aberrant habenula-prefrontal connectivity for the severity of aggressive behavior. This article is part of the Special Issue entitled 'Current status of the neurobiology of aggression and impulsivity'.
在受到挑衅时，表现出不成比例的愤怒和反应性攻击，这是间歇性爆发性障碍（IED）的核心症状。之前的研究表明，在没有挑衅的情况下，健康个体的攻击性倾向与前额叶-边缘和默认模式网络（DMN）在静息状态下的功能异常之间存在联系。在一项初步研究中，我们使用静息状态功能磁共振成像来研究明显的反应性攻击（如 IED）对静息状态大脑网络功能组织的影响，包括先前在临床前模型中与攻击性有关的皮质下节点如缰核。图论被应用于静息状态网络，以确定与低反应性攻击性男性（对照组）相比，高反应性攻击性男性静息状态大脑网络全局效率和聚类的变化。此外，我们计算了特质攻击性与图测量之间的组内相关性，以及特质攻击性与缰核静息状态功能连接（rsFC）之间的组内全脑种子-体素回归分析。与对照组相比，反应性攻击性男性在左侧缰核、丘脑左侧豆状核、左侧背外侧前额叶皮质和右侧颞极的全局效率更高，DMN 节点的聚类也呈下降趋势。在反应性攻击性组中，高水平的特质攻击性与左侧缰核的全局效率降低以及左侧缰核与左侧腹外侧前额叶皮质之间的 rsFC 降低有关，后者是参与抑制控制的核心区域。结合临床前证据，我们在男性中的发现强调了缰核-前额叶连接异常与攻击性行为严重程度的相关性。本文是主题为“攻击性和冲动性神经生物学的现状”的特刊的一部分。
