Iwafuchi M, Watanabe H, Kijima H, Ajioka Y, Shimoda T, Ito S
First Department of Pathology, Niigata University School of Medicine, Japan.
Acta Pathol Jpn. 1987 Aug;37(8):1237-47. doi: 10.1111/j.1440-1827.1987.tb00457.x.
Five argyrophil, non-argentaffin classical carcinoids of the appendix were found in 19 appendiceal classical carcinoids and were investigated histochemically, immunohistochemically and ultrastructurally. All tumors consisted entirely of argyrophil cells. Three of the five carcinoids were composed almost totally of peptide YY cells and were negative for serotonin. One of them consisted of peptide YY cells (60%), somatostatin cells (40%), and a few cells with glucagon-like immunoreactivity (GLI). The remaining one without peptides was homogeneously immunoreactive for serotonin alone. Ultrastructurally, each of the four peptide-positive carcinoids was composed of one kind of endocrine cell type with round secretory granules. Average diameter of granules were 150, 160, 190, and 210 nm, respectively. The non-argentaffin, serotonin-positive carcinoid showed predominant round secretory granules and a few irregular ones, both being 150 nm in largest diameter. It is suggested that the argyrophil, non-argentaffin carcinoids of the appendix are subdivided into two groups; carcinoids composed mainly of peptide (especially, peptide YY)-positive cells with round granules of D1 and/or L cell type and those of serotonin-positive cells with pleomorphic granules of ECn cell type.
在19例阑尾经典类癌中发现5例嗜银、非亲银性阑尾经典类癌，并对其进行了组织化学、免疫组织化学和超微结构研究。所有肿瘤均完全由嗜银细胞组成。5例类癌中有3例几乎完全由肽YY细胞组成，5-羟色胺呈阴性。其中1例由肽YY细胞（60%）、生长抑素细胞（40%）和少数具有胰高血糖素样免疫反应性（GLI）的细胞组成。其余1例无肽类，仅对5-羟色胺呈均匀免疫反应。超微结构上，4例肽阳性类癌中的每一例均由一种具有圆形分泌颗粒的内分泌细胞类型组成。颗粒的平均直径分别为150、160、190和210nm。非亲银性、5-羟色胺阳性类癌显示出主要为圆形分泌颗粒和少数不规则颗粒，最大直径均为150nm。提示阑尾嗜银、非亲银性类癌可分为两组；主要由肽（尤其是肽YY）阳性细胞组成的类癌，其具有D1和/或L细胞类型的圆形颗粒，以及5-羟色胺阳性细胞组成的类癌，其具有ECn细胞类型的多形性颗粒。
