钌（II）催化的 N,N-二烷基硫代苯甲酰胺与硼酸在 2-MeTHF 中的硫配位 C-H 芳基化反应。
Ruthenium(II)-Catalyzed C-H Arylation of N,N-Dialkyl Thiobenzamides with Boronic Acids by Sulfur Coordination in 2-MeTHF.
机构信息
College of Chemistry and Chemical Engineering, Key Laboratory of Chemical Additives for China National Light Industry, Shaanxi University of Science and Technology, Xi'an 710021, China.
State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China.
出版信息
Org Lett. 2020 Sep 4;22(17):6884-6890. doi: 10.1021/acs.orglett.0c02410. Epub 2020 Aug 18.
We report ruthenium(II)-catalyzed -C-H arylation of N,N-dialkylthiobenzamides with boronic acids. The method employs [RuCl(-cym)] in the presence of Cu(OTf) and AgO oxidant. The reaction represents the first example of Ru-catalyzed C-H arylation directed by sulfur-containing groups and a rare example of C-H arylation directed by the versatile thiobenzamide moiety. As a further advantage, the method is performed in sustainable and eco-friendly 2-MeTHF as a solvent.
我们报告了钌（II）催化的 N,N-二烷基硫代苯甲酰胺与硼酸的 -C-H 芳基化反应。该方法采用 [RuCl(-cym)]，在 Cu(OTf) 和 AgO 氧化剂的存在下进行。该反应代表了首例由含硫基团导向的 Ru 催化 C-H 芳基化反应，也是由多功能硫代苯甲酰胺部分导向的 C-H 芳基化反应的罕见例子。作为进一步的优点，该方法在可持续且环保的 2-MeTHF 溶剂中进行。
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